Leukemia & Lymphoma Society

The Leukemia & Lymphoma Society, Inc.

Abbreviation	LLS
Formation	1949; 72 years ago (1949)
Founder	Rudolph and Antoinette Roesler de Villiers[1]
Type	Charity
Legal status	501(c)(3) nonprofit organization
Purpose	Funding blood cancer research, patient and family support services, outreach
Headquarters	3 International Drive, Suite 200, Rye Brook, NY 10573
Coordinates	41°03′01″N 73°41′16″W / 41.0501719°N 73.68790669999998°W / 41.0501719; -73.68790669999998Coordinates: 41°03′01″N 73°41′16″W / 41.0501719°N 73.68790669999998°W / 41.0501719; -73.68790669999998
Region served	United States and Canada
President and CEO	Louis J. DeGennaro, Ph.D.[2]
COO	Rob Beck[2]
Chief of Staff	Danielle Gee[2]
CFO	JR Miller[2]
Subsidiaries	The LLS of Canada, The LLS Research Programs, Inc., The LLS Research Foundation
Affiliations	Barclays, Burlington, Olive Garden, Subaru, UFCW, Walgreens[3]
Website	www.lls.org
Formerly called	Robert Roesler de Villiers Foundation, Leukemia Society of America

The Leukemia & Lymphoma Society (LLS), a 501(c)(3) charitable organization founded in 1949, is the largest voluntary health organization dedicated to fighting blood cancer in the world. The LLS's mission is to cure leukemia, lymphoma, Hodgkin's lymphoma and myeloma, and improve the quality of life of patients and their families.^[4]

LLS is headquartered in Rye Brook, New York, with 56 chapters throughout the United States and five chapters in Canada. LLS has six signature fundraising campaigns: Team In Training, the largest charitable endurance training program in the world; Light The Night, an annual series of community-based walkathons; Man & Woman of the Year, a series of annual ten-week long, community-based competitions in which adults raise funds in honour of local children who have survived blood cancer; Students of the Year, an annual series of seven-week long, community-based fundraising competitions amongst high school students; Leukemia Cup Regatta, a series of fundraising sailing events held by yacht clubs across North America; and Pennies for Patients, a programme providing North American elementary and middle schools with access to STEM curricula. In addition to the main campaigns, there is LLS Lifestyle, in which groups and individuals, through their local chapters, can turn any activity or event into a vehicle for fundraising.

History[]

Originally known as the Robert Roesler de Villiers Foundation, The Leukemia & Lymphoma Society was founded in New York City in 1949 by Rudolph and Antoinette de Villiers after the death of their son Robert from leukemia. The name of the organization was later changed to the Leukemia Society,^[5] then to the Leukemia Society of America in the 1960s, and later to The Leukemia & Lymphoma Society in 2000 to reflect the organization's focus on all types of blood cancer.^[6]

Research[]

Since its founding, The Leukemia & Lymphoma Society has invested more than $1.2 billion (USD) in blood cancer research, funding nearly all of today's most promising treatments.^[7] As there are no means of preventing blood cancers, the LLS research agenda is focused on finding treatments and cures. The organization funds research in areas of unmet medical need and helps to bridge the gap between academic discovery and drug development.

Acute leukemia[]

Acute myeloid leukemia[]

Acute myeloid leukemia (AML) is a rapidly progressing disease that remains one of the most deadly blood cancers, killing more than 10,000 Americans a year. Despite advances in treating other blood cancers, the standard of treatment for AML – a combination of toxic chemotherapies – had changed little over the past four decades. In October 2016, LLS launched its Beat AML Master Clinical Trial, a collaborative precision medicine clinical trial that gives patients targeted therapies based on their genetic markers.^[5]

LLS is leading the Beat AML Master Clinical Trial ^[8] and is the first nonprofit cancer organization to sponsor a clinical trial. The trial consists of a collaboration among multiple leading cancer centres and pharmaceutical companies, a clinical research organization, and a genomics analysis company. The protocol for the trial was developed with input from the U.S. Food and Drug Administration (FDA). The Beat AML Master Clinical Trial is expected to eventually include 500 patients and will continue for at least two years at between 15 and 20 clinical sites.

Acute lymphoblastic leukemia[]

LLS currently contributes hundreds of thousands of dollars per year^{[needs update]} towards research into immunotherapies targeting acute lymphoblastic leukemia (ALL). As part of a wider funding effort including over a dozen other cancer immunotherapy projects, they hope to support more effective and targeted treatments utilizing the human body's own internal attack mechanisms.^[9]

In late 2017, LLS awarded researchers at UNC School of Medicine a $600 thousand grant for clinical research on chimeric antigen receptor (CAR) T cell therapies with an immunosuppressive "safety switch". This approach could mitigate potentially lethal side effects of immunotherapy—such as cytokine release syndrome—for ALL treatments by halting the activity of infused T cells, in the event of a patient experiencing treatment toxicity.^[9]

Patient Support[]

The Leukemia & Lymphoma Society is a source of blood cancer information, education and support for patients, survivors, families and healthcare professionals.

In 1997, LLS created the Information Resource Center (IRC) to provide blood cancer patients, their families and health professionals with accurate, current disease information, resources and support.^[5][10] LLS Blood Cancer Information Specialists are master's level oncology social workers, nurses and health educators. An Information Specialist can assist patients through cancer treatment, financial and social challenges and give accurate, up-to-date disease, treatment and support information.

As a community-based voluntary health organization, LLS has regional and local chapters throughout the United States and Canada to support blood cancer patients in every community.^[11]

Advocacy[]

The Leukemia & Lymphoma Society's Office of Public Policy pursues LLS's mission through advocacy aimed at governmental decision-makers.

Through LLS's nationwide grassroots network of more than 100,000 volunteers, the organization advocates for policies at the state and federal level to remove barriers to care for blood cancer patients. These efforts include helping to increase federal research funds, speed the review and approval process of new therapies, and ensure patients are able to access their treatments.

LLS also advocates for public policy positions that accelerate progress toward cures for leukemia, Hodgkin and non-Hodgkin lymphoma and myeloma, and to improve the quality of life of those with blood cancer, their friends and families.^[12]

References[]