Liver kidney microsomal type 1 antibody

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Immunofluorescence pattern of LKM1 antibodies on liver (left) and kidney (right). Staining of proximal tubules can be observerved on the kidney, whereas distal tubules remain unstained.

Liver kidney microsomal type 1 antibody is an autoantibody associated with autoimmune hepatitis.[1] It is one of the several subtypes of anti–liver-kidney microsome antibodies that are known. The frequent association of anti-LKM-1 antibodies and hepatitis C virus (HCV) infections and the probable existence of an infectious and autoimmune form of anti-LKM-1-associated hepatitis, requiring different therapeutical strategies, necessitates the exact determination of anti-LKM-1 specificities.

References[]

  1. ^ Kerkar N, Ma Y, Davies ET, Cheeseman P, Mieli-Vergani G, Vergani D (December 2002). "Detection of liver kidney microsomal type 1 antibody using molecularly based immunoassays". J. Clin. Pathol. 55 (12): 906–909. doi:10.1136/jcp.55.12.906. PMC 1769836. PMID 12461054.


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