Louis Pillemer

Louis Pillemer (1908 – August 31, 1957), was an American immunologist, an early investigator of the alternative complement pathway (a system of defense not dependent upon antibodies.)

Biography[]

Pillemer was born in Johannesburg, South Africa, in 1908, the son of Lithuanian parents. He was brought to the United States at the age of one year, and was naturalized in 1916. He attended public schools in Catlettsburg and Ashland, Kentucky, and began collegiate work at Ohio State University in Columbus, Ohio, later attending Marshall College at Huntington, West Virginia, and Duke University at Durham, North Carolina. At Duke he received a B.S. degree in 1932, and also completed two years in medicine.

Found dead at his home in Cleveland Heights, Ohio, at the age of 49 years. His death was ruled a suicide. He was survived by a wife and four young sons.^[1]

Discoveries[]

He led a team at Western Reserve University which discovered properdin in 1954,^[2] and this discovery received attention from the national press as a breakthrough in immunology.^[3]

In 1957, Robert Nelson challenged these findings, and claimed that Pillemer's results were due to laboratory errors.^[4] Pillemer's death soon after publications was ruled a suicide.

Nelson's view prevailed at the time, but further study in the 1960s largely led to a confirmation of much of Pillemer's work.^[5][6]

References[]

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