MBOAT7

MBOAT7
Identifiers
Aliases	MBOAT7, BB1, LENG4, LPIAT, LRC4, MBOA7, OACT7, hMBOA-7, membrane bound O-acyltransferase domain containing 7, MRT57, LPLAT
External IDs	OMIM: 606048 MGI: 1924832 HomoloGene: 11510 GeneCards: MBOAT7
EC number	2.3.1.n4
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,189,882 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	3,693,523 bp
RNA expression pattern
	Top expressed in
	blood; ; hypothalamus; ; adrenal gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; acyltransferase activity; GO:0001948 protein binding; 2-acylglycerol-3-phosphate O-acyltransferase activity; 1-acylglycerol-3-phosphate O-acyltransferase activity; lysophospholipid acyltransferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; mitochondria-associated endoplasmic reticulum membrane; endoplasmic reticulum;
Biological process	phosphatidylinositol acyl-chain remodeling; phosphatidylinositol metabolic process; ventricular system development; lipid metabolism; phospholipid biosynthetic process; phospholipid metabolic process; layer formation in cerebral cortex;
	Sources:Amigo / QuickGO
Orthologs
	79143
	77582
ENSG00000273592; ENSG00000278519; ENSG00000274194; ENSG00000125505; ENSG00000277025;
	ENSG00000275118; ENSG00000276935; ENSG00000277733; ENSG00000277923; ENSG00000278322
	ENSMUSG00000035596
	Q96N66
	Q8CHK3
	NM_001146056; NM_001146082; NM_001146083; NM_024298
	NM_029934
	NP_001139528; NP_001139554; NP_001139555; NP_077274
	NP_084210
	Wikidata
View/Edit Human	View/Edit Mouse

Lysophospholipid acyltransferase 7 also known as membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) is an enzyme that in humans is encoded by the MBOAT7 gene.^[5] It is homologous to other membrane-bound O-acyltransferases.

Function[]

This gene encodes a member of the membrane-bound O-acyltransferases family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the re-acylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle.^[5]

References[]

^ ^a ^b ^c ENSG00000278519, ENSG00000274194, ENSG00000125505, ENSG00000277025, ENSG00000275118, ENSG00000276935, ENSG00000277733, ENSG00000277923, ENSG00000278322 GRCh38: Ensembl release 89: ENSG00000273592, ENSG00000278519, ENSG00000274194, ENSG00000125505, ENSG00000277025, ENSG00000275118, ENSG00000276935, ENSG00000277733, ENSG00000277923, ENSG00000278322 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035596 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Membrane bound O-acyltransferase domain containing 7".

Further reading[]

Wende H, Volz A, Ziegler A (July 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842. S2CID 20719684.
Lee HC, Inoue T, Imae R, Kono N, Shirae S, Matsuda S, Gengyo-Ando K, Mitani S, Arai H (March 2008). "Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol". Mol. Biol. Cell. 19 (3): 1174–84. doi:10.1091/mbc.E07-09-0893. PMC 2262980. PMID 18094042.
Shindou H, Hishikawa D, Harayama T, Yuki K, Shimizu T (April 2009). "Recent progress on acyl CoA: lysophospholipid acyltransferase research". J. Lipid Res. 50 Suppl: S46–51. doi:10.1194/jlr.R800035-JLR200. PMC 2674719. PMID 18931347.
Gijón MA, Riekhof WR, Zarini S, Murphy RC, Voelker DR (October 2008). "Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils". J. Biol. Chem. 283 (44): 30235–45. doi:10.1074/jbc.M806194200. PMC 2573059. PMID 18772128.
Fukunaga-Johnson N, Lee SW, Liebert M, Grossman HB (1996). "Molecular analysis of a gene, BB1, overexpressed in bladder and breast carcinoma". Anticancer Res. 16 (3A): 1085–90. PMID 8702217.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] ENSG00000278519, ENSG00000274194, ENSG00000125505, ENSG00000277025, ENSG00000275118, ENSG00000276935, ENSG00000277733, ENSG00000277923, ENSG00000278322 GRCh38: Ensembl release 89: ENSG00000273592, ENSG00000278519, ENSG00000274194, ENSG00000125505, ENSG00000277025, ENSG00000275118, ENSG00000276935, ENSG00000277733, ENSG00000277923, ENSG00000278322 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035596 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Membrane bound O-acyltransferase domain containing 7".

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