MDN1, midasin homolog (yeast) is a protein that in humans is encoded by the MDN1 gene .[5] AAA ATPase family.
Model organisms [ ] Model organisms have been used in the study of MDN1 function. A conditional knockout mouse line, called Mdn1tm1a(KOMP)Wtsi [10] [11] International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[12] [13] [14]
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[8] [15] mutant mice and three significant abnormalities were observed.[8] homozygous mutant embryos were identified during gestation, and therefore none survived until weaning . The remaining tests were carried out on heterozygous mutant adult mice; females had an increased susceptibility to bacterial infection .[8]
References [ ]
^ a b c ENSG00000288121 GRCh38: Ensembl release 89: ENSG00000112159, ENSG00000288121 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058006 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: MDN1, midasin homolog (yeast)" . Retrieved 2011-09-20 .^ "Salmonella infection data for Mdn1" . Wellcome Trust Sanger Institute.^ "Citrobacter infection data for Mdn1" . Wellcome Trust Sanger Institute.^ a b c d Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica . 88 : 925–7. doi :10.1111/j.1755-3768.2010.4142.x . S2CID 85911512 . ^ Mouse Resources Portal , Wellcome Trust Sanger Institute.^ "International Knockout Mouse Consortium" .^ "Mouse Genome Informatics" .^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function" . Nature . 474 (7351): 337–342. doi :10.1038/nature10163 . PMC 3572410 PMID 21677750 . ^ Dolgin E (2011). "Mouse library set to be knockout" . Nature . 474 (7351): 262–3. doi :10.1038/474262a PMID 21677718 . ^ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons" . Cell . 128 (1): 9–13. doi :10.1016/j.cell.2006.12.018 PMID 17218247 . S2CID 18872015 . ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism" . Genome Biol . 12 (6): 224. doi :10.1186/gb-2011-12-6-224 . PMC 3218837 PMID 21722353 .
Further reading [ ]
