Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A is an enzyme that in humans is encoded by the MGAT5gene.[5][6]
This gene encodes mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, a glycosyltransferase involved in the synthesis of protein-bound and lipid-bound oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the encoded protein's activity may correlate with the progression of invasive malignancies.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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Granovsky M, Fata J, Pawling J, et al. (2000). "Suppression of tumor growth and metastasis in Mgat5-deficient mice". Nat. Med. 6 (3): 306–12. doi:10.1038/73163. PMID10700233. S2CID1950342.
Kim CH (2005). "Increased expression of N-acetylglucosaminyltransferase-V in human hepatoma cells by retinoic acid and 1alpha,25-dihydroxyvitamin D3". Int. J. Biochem. Cell Biol. 36 (11): 2307–19. doi:10.1016/j.biocel.2004.04.021. PMID15313475.
Tomiie M, Isaka S, Miyoshi E, et al. (2005). "Elevated expression of N-acetylglucosaminyltransferase V in first trimester human placenta". Biochem. Biophys. Res. Commun. 330 (3): 999–1004. doi:10.1016/j.bbrc.2005.02.186. PMID15809094.
Li J, Wang XM, Wang Q, et al. (2007). "Down-regulation of N-acetylglucosaminyltransferase-V induces ER stress by changing glycosylation and function of GLUT1". Arch. Biochem. Biophys. 463 (1): 102–9. doi:10.1016/j.abb.2007.03.005. PMID17451637.