MICAL3

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MICAL3

Protein MICAL3 PDB 2d88.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2D88

Identifiers

MICAL3, MICAL-3, microtubule associated monooxygenase, calponin and LIM domain containing 3

External IDs

OMIM: 608882 MGI: 2442733 HomoloGene: 85288 GeneCards: MICAL3

Gene location (Human)

Chr.	Chromosome 22 (human)^[1]

Band	22q11.21	Start	17,787,649 bp^[1]
Band	22q11.21	End	18,024,561 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6\|6 F1	Start	120,931,707 bp^[2]
Band	6\|6 F1	End	121,130,999 bp^[2]

RNA expression pattern

Top expressed in
cerebellum sural nerve left ventricle corpus callosum cerebellar hemisphere muscle of leg
More reference expression data

n/a

Gene ontology
Molecular function	monooxygenase activity oxidoreductase activity actin binding FAD binding metal ion binding GO:0001948 protein binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
Cellular component	plasma membrane cytoskeleton nucleus nucleoplasm cytoplasm cytosol spindle cell cortex midbody cell projection
Biological process	actin filament depolymerization cytoskeleton organization exocytosis cell cycle cell division
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


57553


194401

Ensembl


ENSG00000243156


ENSMUSG00000051586


Q7RTP6


Q8CJ19

RefSeq (mRNA)


NM_001122731 NM_001136004 NM_015241 NM_020793


NM_001270475 NM_153396

RefSeq (protein)


NP_001116203 NP_001129476 NP_056056


NP_001257404 NP_700445

Location (UCSC)

Chr 22: 17.79 – 18.02 Mb

Chr 6: 120.93 – 121.13 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Microtubule-associated monoxygenase, calponin and LIM domain containing 3, also known as MICAL3, is a human gene.^[5]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000243156 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051586 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MICAL3 microtubule associated monoxygenase, calponin and LIM domain containing 3".

Further reading[]

Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Terman JR, Mao T, Pasterkamp RJ, et al. (2002). "MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion". Cell. 109 (7): 887–900. doi:10.1016/S0092-8674(02)00794-8. PMID 12110185.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Fischer J, Weide T, Barnekow A (2005). "The MICAL proteins and rab1: a possible link to the cytoskeleton?". Biochem. Biophys. Res. Commun. 328 (2): 415–23. doi:10.1016/j.bbrc.2004.12.182. PMID 15694364.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

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2d88: Solution structure of the CH domain from human MICAL-3 protein

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