MOBKL1A

MOB1B
Identifiers
Aliases	MOB1B, MATS2, MOB4A, MOBKL1A, MOB kinase activator 1B
External IDs	OMIM: 609282 MGI: 1915723 HomoloGene: 61676 GeneCards: MOB1B
Gene location (Human)
Chr.	Chromosome 4 (human)
End	71,022,449 bp
Gene ontology
Molecular function	• kinase binding; • GO:0001948 protein binding; • kinase activator activity; • metal ion binding;
Cellular component	• cytoplasm; • extracellular exosome; • nucleus; • nucleolus; • cytosol;
Biological process	• regulation of protein autophosphorylation; • hippo signaling; • positive regulation of phosphorylation; • positive regulation of kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	92597
	68473
	ENSG00000173542
	ENSMUSG00000006262
	Q7L9L4
	Q8BPB0
	NM_001244766; NM_001244767; NM_173468
	NM_026735
	NP_001231695; NP_001231696; NP_775739
	NP_081011
	Wikidata
View/Edit Human	View/Edit Mouse

Mps one binder kinase activator-like 1A, also known as Mob1 homolog 1A, is a protein that in humans is encoded by the MOBKL1A gene.^[4]^[5]

Function[]

The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation.^[4]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173542 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: MOB1".
^ Devroe E, Erdjument-Bromage H, Tempst P, Silver PA (June 2004). "Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases". J. Biol. Chem. 279 (23): 24444–51. doi:10.1074/jbc.M401999200. PMID 15067004.

Further reading[]

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Bichsel SJ, Tamaskovic R, Stegert MR, Hemmings BA (2004). "Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein". J. Biol. Chem. 279 (34): 35228–35. doi:10.1074/jbc.M404542200. PMID 15197186.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chow A, Hao Y, Yang X (2010). "Molecular characterization of human homologs of yeast MOB1". Int. J. Cancer. 126 (9): 2079–89. doi:10.1002/ijc.24878. PMID 19739119. S2CID 33688672.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173542 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: MOB1".

[pmid15067004-5] Devroe E, Erdjument-Bromage H, Tempst P, Silver PA (June 2004). "Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases". J. Biol. Chem. 279 (23): 24444–51. doi:10.1074/jbc.M401999200. PMID 15067004.

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[2]

[3]

[4]

[5]

v t Signaling pathway: Hippo signaling pathway
Receptor	FAT4
Adaptor protein	NF2 FRMD6 SAV1 MOBKL1A MOBKL1B
Kinase	MST1 LATS1 LATS2 STK3
Transcription factor	YAP1 TAZ
Other/unknown	RASSF1

MOBKL1A

Contents

Function[]

See also[]

References[]

Further reading[]