MOS (gene)

MOS
Identifiers
Aliases	MOS, MSV, v-mos Moloney murine sarcoma viral oncogene homolog, MOS proto-oncogene, serine/threonine kinase
External IDs	OMIM: 190060 MGI: 97052 HomoloGene: 3919 GeneCards: MOS
Gene location (Human)
Chr.	Chromosome 8 (human)
End	56,113,982 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	3,872,105 bp
RNA expression pattern
	Top expressed in
	amygdala; ; muscle tissue; ; testicle; ; substantia nigra; ; central nervous system; ; hippocampus proper; ; cerebrum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; GO:0001948 protein binding; MAP kinase kinase kinase activity; ATP binding; kinase activity; protein serine/threonine kinase activity; signal transducer activity;
Cellular component	cytoplasm; cytosol;
Biological process	protein autophosphorylation; establishment of meiotic spindle orientation; chromatin organization; GO:0043147 meiotic spindle organization; phosphorylation; MAPK cascade; GO:0007243 intracellular signal transduction; positive regulation of MAPK cascade; negative regulation of metaphase/anaphase transition of meiotic cell cycle; protein phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	4342
	17451
	ENSG00000172680
	ENSMUSG00000078365
	P00540
	P00536
	NM_005372
	NM_020021
	NP_005363
	NP_064405
	Wikidata
View/Edit Human	View/Edit Mouse

Proto-oncogene serine/threonine-protein kinase mos is an enzyme that in humans is encoded by the MOS gene.^[5]^[6]

Interactions[]

MOS (gene) has been shown to interact with MyoD.^[7]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172680 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000078365 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Singh B, Arlinghaus RB (May 1998). "Mos and the cell cycle". Prog Cell Cycle Res. 3: 251–9. doi:10.1007/978-1-4615-5371-7_20. ISBN 978-1-4613-7451-0. PMID 9552420.
^ "Entrez Gene: MOS v-mos Moloney murine sarcoma viral oncogene homolog".
^ Lenormand, J L; Benayoun B; Guillier M; Vandromme M; Leibovitch M P; Leibovitch S A (Feb 1997). "Mos activates myogenic differentiation by promoting heterodimerization of MyoD and E12 proteins". Mol. Cell. Biol. UNITED STATES. 17 (2): 584–93. doi:10.1128/mcb.17.2.584. ISSN 0270-7306. PMC 231783. PMID 9001211.

Further reading[]

Sagata N (1997). "What does Mos do in oocytes and somatic cells?". BioEssays. 19 (1): 13–21. doi:10.1002/bies.950190105. PMID 9008413. S2CID 1338222.
Caubet JF, Mathieu-Mahul D, Bernheim A, et al. (1986). "Human proto-oncogene c-mos maps to 8q11". EMBO J. 4 (9): 2245–8. doi:10.1002/j.1460-2075.1985.tb03921.x. PMC 554492. PMID 3000766.
Watson R, Oskarsson M, Vande Woude GF (1982). "Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus". Proc. Natl. Acad. Sci. U.S.A. 79 (13): 4078–82. Bibcode:1982PNAS...79.4078W. doi:10.1073/pnas.79.13.4078. PMC 346580. PMID 6287464.
Heikinheimo O, Lanzendorf SE, Baka SG, Gibbons WE (1995). "Cell cycle genes c-mos and cyclin-B1 are expressed in a specific pattern in human oocytes and preimplantation embryos". Hum. Reprod. 10 (3): 699–707. doi:10.1093/oxfordjournals.humrep.a136019. PMID 7540181.
Lenormand JL, Benayoun B, Guillier M, et al. (1997). "Mos activates myogenic differentiation by promoting heterodimerization of MyoD and E12 proteins". Mol. Cell. Biol. 17 (2): 584–93. doi:10.1128/mcb.17.2.584. PMC 231783. PMID 9001211.
Liu H, Vuyyuru VB, Pham CD, et al. (1999). "Evidence of an interaction between Mos and Hsp70: a role of the Mos residue serine 3 in mediating Hsp70 association". Oncogene. 18 (23): 3461–70. doi:10.1038/sj.onc.1202699. PMID 10376524.
Pham CD, Vuyyuru VB, Yang Y, et al. (1999). "Evidence for an important role of serine 16 and its phosphorylation in the stabilization of c-Mos". Oncogene. 18 (30): 4287–94. doi:10.1038/sj.onc.1202804. PMID 10439036.
Proikas-Cezanne T, Stabel S, Riethmacher D (2002). "Identification of protein tyrosine phosphatase 1B and casein as substrates for 124-v-Mos". BMC Biochem. 3: 6. doi:10.1186/1471-2091-3-6. PMC 102758. PMID 12022922.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hassel S, Eichner A, Yakymovych M, et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry". Proteomics. 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID 15188402. S2CID 6773754.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kalejs M, Ivanov A, Plakhins G, et al. (2006). "Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and induction of mitotic catastrophe". BMC Cancer. 6: 6. doi:10.1186/1471-2407-6-6. PMC 1351196. PMID 16401344.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172680 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000078365 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9552420-5] Singh B, Arlinghaus RB (May 1998). "Mos and the cell cycle". Prog Cell Cycle Res. 3: 251–9. doi:10.1007/978-1-4615-5371-7_20. ISBN 978-1-4613-7451-0. PMID 9552420.

[entrez-6] "Entrez Gene: MOS v-mos Moloney murine sarcoma viral oncogene homolog".

[pmid9001211-7] Lenormand, J L; Benayoun B; Guillier M; Vandromme M; Leibovitch M P; Leibovitch S A (Feb 1997). "Mos activates myogenic differentiation by promoting heterodimerization of MyoD and E12 proteins". Mol. Cell. Biol. UNITED STATES. 17 (2): 584–93. doi:10.1128/mcb.17.2.584. ISSN 0270-7306. PMC 231783. PMID 9001211.

[1]

[2]

[3]

[4]

[5]

[6]

[7]