Malcolm Stevens

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For the footballer, see Malcolm Stephens.
Malcolm Stevens

OBE, FRS
Born
Malcolm Francis Graham Stevens

1938 (age 83–84)
CitizenshipBritish
EducationBolton School
Alma materUniversity of Nottingham
Spouse(s)Valerie Deans (m.1961)

Malcolm Francis Graham Stevens OBE, FRS (born 1938)[1] is an English chemist and Emeritus professor of the University of Nottingham, having previously worked at Aston University where he developed the cancer drug temozolomide.[2][3]

Education and family[]

Stevens attended Bolton School, Lancashire, and then obtained a BSc and PhD at the University of Nottingham.[4]

He married Valerie Deans at Christ Church, Heaton, Bolton, in 1961.[5][6]

Career[]

Stevens took up a post of Reader in the Department of Pharmaceutical Sciences at Aston University in 1972, and was later appointed Professor. He headed the Cancer Research UK Experimental Cancer Chemotherapy group from 1980 to 2006, moving to the University of Nottingham in 1992.[3][7] Stevens's lab synthesised Temozolomide, which as of 2019, remains the only FDA-approved drug to treat the deadly brain tumor Glioblastoma multiforme. Temozolomide has had a substantial impact in the clinic: the 5-year survival with radiation alone is 4%, whilst with radiation plus temozolomide, it approaches 17%. The 10 year survival without temozolomide is <1% versus around 8% with temozolomide. Thus, long term survivorship with GBM is now possible (if not common), thanks to the work of Stevens and his group.[8][9]

Recognition[]

Stevens was appointed OBE in the 1999 New Year Honours "For services to the development of Cancer Drugs", being described as "Professor of Experimental Cancer Chemotherapy, University of Nottingham".[10] He was elected a Fellow of the Royal Society in 2009.[2]

References[]

  1. ^ "Birth index entry". FreeBMD. ONS. September 1961. Retrieved 6 September 2017.
  2. ^ a b "Malcolm Stevens". The Royal Society. Retrieved 5 September 2017.
  3. ^ a b "Malcolm Stevens". School of Pharmacy. University of Nottingham. Retrieved 5 September 2017.
  4. ^ "100 Inspiring Minds – Professor Malcolm Stevens OBE, FRS". Bolton School. Archived from the original on 6 September 2017. Retrieved 5 September 2017.
  5. ^ "Marriage index entry". FreeBMD. ONS. September 1961. Retrieved 6 September 2017.
  6. ^ "Marriage Indexes". lancashirebmd.org.uk. Retrieved 6 September 2017.
  7. ^ "Professor Malcolm Stevens OBE, FRS". 50 Aston Greats. Aston University. Retrieved 5 September 2017.
  8. ^ Weller, Michael; et al. (17 June 2019). "How we treat glioblastoma". ESMO Open. 4 (Suppl 2): e000520. doi:10.1136/esmoopen-2019-000520. PMC 6586206. PMID 31297242.
  9. ^ Stupp, Roger; et al. (10 March 2005). "Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma". New England Journal of Medicine. 352 (10): 987–996. doi:10.1056/NEJMoa043330. PMID 15758009.
  10. ^ "No. 55354". The London Gazette (Supplement). 31 December 1998. p. 13.

External links[]

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