Mark Daly (scientist)
Mark Daly | |
---|---|
Born | September 15, 1967 |
Alma mater | Massachusetts Institute of Technology |
Known for | |
Awards | Curt Stern Award, National Academy of Medicine |
Scientific career | |
Institutions | Broad Institute of MIT and Harvard Massachusetts General Hospital Harvard University Institute for Molecular Medicine (FIMM) at the University of Helsinki |
Doctoral advisors | Eric Lander Gert-Jan van Ommen |
Mark Joseph Daly is Director of the Finnish Institute for Molecular Medicine (FIMM) at the University of Helsinki,[1] a Professor of Genetics at Harvard Medical School, Chief of the Analytic and Translational Genetic Unit at Massachusetts General Hospital, and a member of the Broad Institute of MIT and Harvard.[2] In the early days of the Human Genome Project, Daly helped develop the genetic model by which linkage disequilibrium could be used to map the haplotype structure of the human genome.[3] In addition, he developed statistical methods to find associations between genes and disorders such as Crohn's disease,[4] inflammatory bowel disease, autism and schizophrenia.[5]
Daly is considered a pioneer in the field of human genetics, and is amongst the most cited scientists in the field,[5] and one of the top 100 most cited scientists of all time.[6] He was elected to the National Academy of Medicine in 2017.[7]
Education[]
Daly studied physics at MIT, although he initially wanted to become a lawyer or poker player, he joined Eric Lander as a freshman.[8] Mark continued to work with Lander, before eventually receiving his PhD from Leiden University in 2004.
Research[]
Daly trained with Eric Lander at the Whitehead Institute, and most of his initial efforts were to map haplotypes across the human genome. During his time there, his team developed , , Haploview, PLINK, and . Collectively these tools have received over 30,000 citations. As genome sequencing has become cheaper, his group works on developing statistical methods to implicate genetic mutations in neuropsychiatric diseases.[9][10]
References[]
- ^ "Unique Finnish genomics scene attracts top US scientist to University of Helsinki | University of Helsinki". University of Helsinki. 2018-02-07. Retrieved 2018-11-19.
- ^ "Mark Daly - Broad Institute". Broadinstitute.org. 2015-06-29. Retrieved 20 July 2017.
- ^ Daly, Mark J.; Rioux, John D.; Schaffner, Stephen F.; Hudson, Thomas J.; Lander, Eric S. (1 October 2001). "High-resolution haplotype structure in the human genome". Nature Genetics. 29 (2): 229–232. doi:10.1038/ng1001-229. PMID 11586305. S2CID 9619343.
- ^ Mark J. Daly, Jeffrey C Barrett; et al. (1 June 2008). "Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease". Nature Genetics. 40 (2): 955–962. doi:10.1038/ng.175. PMC 2574810. PMID 18587394.
- ^ Jump up to: a b "ASHG Honors Gonçalo R. Abecasis and Mark J. Daly with Curt Stern Award - ASHG". www.ashg.org. 2014-07-02. Retrieved 4 August 2017.
- ^ "1612 Highly Cited Researchers (h>100) according to their Google Scholar Citations public profiles - Ranking Web of Universities". www.webometrics.info. Retrieved 4 August 2017.
- ^ "National Academy of Medicine Elects 80 New Members". 2017-10-16.
- ^ "Lens :: A New Way of Looking at Science -- Eric Lander: The great amplifier". www.mc.vanderbilt.edu. Retrieved 4 August 2017.
- ^ Neale, Benjamin M.; Kou, Yan; Liu, Li; Ma'ayan, Avi; Samocha, Kaitlin E.; Sabo, Aniko; Lin, Chiao-Feng; Stevens, Christine; Wang, Li-San; Makarov, Vladimir; Polak, Paz; Yoon, Seungtai; Maguire, Jared; Crawford, Emily L.; Campbell, Nicholas G.; Geller, Evan T.; Valladares, Otto; Shafer, Chad; Liu, Han; Zhao, Tuo; Cai, Guiqing; Lihm, Jayon; Dannenfelser, Ruth; Jabado, Omar; Peralta, Zuleyma; Nagaswamy, Uma; Muzny, Donna; Reid, Jeffrey G.; Newsham, Irene; Wu, Yuanqing; Lewis, Lora; Han, Yi; Voight, Benjamin F.; Lim, Elaine; Rossin, Elizabeth; Kirby, Andrew; Flannick, Jason; Fromer, Menachem; Shakir, Khalid; Fennell, Tim; Garimella, Kiran; Banks, Eric; Poplin, Ryan; Gabriel, Stacey; DePristo, Mark; Wimbish, Jack R.; Boone, Braden E.; Levy, Shawn E.; Betancur, Catalina; Sunyaev, Shamil; Boerwinkle, Eric; Buxbaum, Joseph D.; Cook, Edwin H.; Devlin, Bernie; Gibbs, Richard A.; Roeder, Kathryn; Schellenberg, Gerard D.; Sutcliffe, James S.; Daly, Mark J. (4 April 2012). "Patterns and rates of exonic de novo mutations in autism spectrum disorders". Nature. 485 (7397): 242–245. doi:10.1038/nature11011. PMC 3613847. PMID 22495311.
- ^ Samocha, Kaitlin E.; Robinson, Elise B.; Sanders, Stephan J.; Stevens, Christine; Sabo, Aniko; McGrath, Lauren M.; Kosmicki, Jack A.; Rehnström, Karola; Mallick, Swapan; Kirby, Andrew; Wall, Dennis P.; MacArthur, Daniel G.; Gabriel, Stacey B.; DePristo, Mark; Purcell, Shaun M.; Palotie, Aarno; Boerwinkle, Eric; Buxbaum, Joseph D.; Cook Jr, Edwin H.; Gibbs, Richard A.; Schellenberg, Gerard D.; Sutcliffe, James S.; Devlin, Bernie; Roeder, Kathryn; Neale, Benjamin M.; Daly, Mark J. (1 September 2014). "A framework for the interpretation of de novo mutation in human disease". Nature Genetics. 46 (9): 944–950. doi:10.1038/ng.3050. PMC 4222185. PMID 25086666.
- Living people
- 1968 births
- American geneticists
- Genetic epidemiologists
- Harvard Medical School faculty
- Massachusetts Institute of Technology School of Science alumni
- Leiden University alumni
- American expatriates in Finland