Masoprocol

Masoprocol
Clinical data
Trade names	Actinex
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of; administration	Topical
ATC code	L01XX10 (WHO) ;
Pharmacokinetic data
Bioavailability	Very low
Identifiers
	IUPAC name 4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol;
CAS Number	27686-84-6 ;
PubChem CID	71398;
IUPHAR/BPS	4265;
DrugBank	DB00179 ;
ChemSpider	64490 ;
UNII	7BO8G1BYQU;
ChEBI	CHEBI:73468 ;
ChEMBL	ChEMBL313972 ;
CompTox Dashboard (EPA)	DTXSID5045178 ;
ECHA InfoCard	100.044.172
Chemical and physical data
Formula	C18H22O4
Molar mass	302.370 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Oc1ccc(cc1O)C[C@H](C)[C@H](C)Cc2ccc(O)c(O)c2;
	InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+ ; Key:HCZKYJDFEPMADG-TXEJJXNPSA-N ;
	(what is this?)

Masoprocol is an antineoplastic drug used to treat skin growths caused by sun exposure. A form of nordihydroguaiaretic acid that is taken by mouth is being studied in the treatment of prostate cancer.

Also called nordihydroguaiaretic acid, NDGA, and actinex.

Mechanism[]

Nordihydroguaiaretic acid is an antioxidant, and it may block certain enzymes needed for tumor growth.

It is a lipoxygenase inhibitor.^[1]

References[]

^ Gowri MS, Azhar RK, Kraemer FB, Reaven GM, Azhar S (September 2000). "Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL". American Journal of Physiology. Endocrinology and Metabolism. 279 (3): E593-600. doi:10.1152/ajpendo.2000.279.3.E593. PMID 10950827.

External links[]

MedlinePlus Drug Information
Actinex entry in the public domain NCI Cancer Dictionary

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[1] Gowri MS, Azhar RK, Kraemer FB, Reaven GM, Azhar S (September 2000). "Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL". American Journal of Physiology. Endocrinology and Metabolism. 279 (3): E593-600. doi:10.1152/ajpendo.2000.279.3.E593. PMID 10950827.

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