Mendelian traits in humans

From Wikipedia, the free encyclopedia
Autosomal dominant
A 50/50 chance of inheritance.
Sickle-cell disease is inherited in the autosomal recessive pattern. When both parents have sickle-cell trait (carrier), a child has a 25% chance of sickle-cell disease (red icon), 25% do not carry any sickle-cell alleles (blue icon), and 50% have the heterozygous (carrier) condition.[1]
If one parent has sickle-cell anaemia and the other has sickle-cell trait, then the child has a 50% chance of having sickle-cell disease and a 50% chance of having sickle-cell trait.[1]
An example of the codominant inheritance of some of the four blood groups.

Mendelian traits in humans concerns how, in Mendelian inheritance, a child receiving a dominant allele from either parent will have the dominant form of the phenotypic trait or characteristic. Only those that received the recessive allele from both parents, known as zygosity, will have the recessive phenotype. Those that receive a dominant allele from one parent and a recessive allele from the other parent will have the dominant form of the trait. Purely Mendelian traits are a tiny minority of all traits, since most phenotypic traits exhibit incomplete dominance, codominance, and contributions from many genes.

The recessive phenotype may theoretically skip any number of generations, lying dormant in heterozygous "carrier" individuals until they have children with someone who also has the recessive allele and both pass it on to their child.

Examples[]

These traits include:


References[]

  1. ^ Jump up to: a b "Inheritance of Sickle Cell Anaemia – Sickle Cell Society". Archived from the original on 2018-03-27. Retrieved 2015-12-29.
  2. ^ Jump up to: a b c d e f g h i j k l m n o p q r s Klug, William S.; Cummings, Michael R.; Spencer, Charlotte A.; Palladino, Michael A. (2012). Essentials of Genetics. Pearson. ISBN 978-0-321-80311-5.
  3. ^ Sowińska-Seidler, Anna; Socha, Magdalena; Jamsheer, Aleksander (October 2013). "Split-hand/foot malformation - molecular cause and implications in genetic counseling". Journal of Applied Genetics. 55 (1): 105–115. doi:10.1007/s13353-013-0178-5. PMC 3909621. PMID 24163146.
  4. ^ Hollfelder, Nina; Bibiker, Hiba; Granehäll, Lena; Schlebusch, Carina; Jakobsson, Matthias (April 2020). "The genetic variation of lactase persistence alleles in northeast Africa". bioRxiv 10.1101/2020.04.23.057356.
  5. ^ "Myths of Human Genetics: Earwax".

Further reading[]

External links[]

Retrieved from ""