Mesangial proliferative glomerulonephritis
| Mesangial proliferative glomerulonephritis | |
|---|---|
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| Renal corpuscle showing intraglomerular mesangium. | |
| Specialty | Nephrology  |
Mesangial proliferative glomerulonephritis is a form of glomerulonephritis associated primarily with the mesangium.[1] There is some evidence that interleukin-10 may inhibit it in an animal model.[2] It is classified as type II lupus nephritis by the World Health Organization (WHO).
Common shorthand for the condition is MesPGN.
Mechanism[]
Mesangial cells in the renal glomerulus use endocytosis to take up and degrade circulating immunoglobulin. This normal process stimulates mesangial cell proliferation and matrix deposition. Therefore, during times of elevated circulating immunoglobulin (i.e. lupus and IgA nephropathy) one would expect to see an increased number of mesangial cells and matrix in the glomerulus. This is characteristic of nephrotic syndromes.[citation needed]
Diagnosis[]
The clinical presentation of MesPGN is varied, although persistent or recurring microscopic or macroscopic hematuria with mild proteinuria is most common.[citation needed]
Studies are performed in most patients to exclude known causes. MesPGN can also be a finding in resolving postinfectious. Isolated deposits with scanty subendothelial or subepithelial (hump-like) deposits on electron microscopy may be seen in this situation indicating a likelihood of MesPGN.[3]
Treatment[]
Approximately 50% of patients with this histologic lesion respond to corticosteroid therapy.[4]
References[]
- ^ "Definition: mesangial proliferative glomerulonephritis from Online Medical Dictionary".
- ^ Kitching, A. R.; Katerelos, M.; Mudge, S. J.; Tipping, P. G.; Power, D. A.; Holdsworth, S. R. (2002). "Interleukin-10 inhibits experimental mesangial proliferative glomerulonephritis". Clinical & Experimental Immunology. 128 (1): 36–43. doi:10.1046/j.1365-2249.2002.01793.x. PMC 1906377. PMID 11982588.
- ^ Glassock, Richard J. (2010). "Other Glomerular Disorders and Antiphospholipid Syndrome". Comprehensive Clinical Nephrology. pp. 335–343. doi:10.1016/B978-0-323-05876-6.00027-7. ISBN 9780323058766.
- ^ Nelson textbook of pediatrics. Robert Kliegman, Bonita Stanton, Joseph W., III St. Geme, Nina Felice Schor, Richard E. Behrman, Waldo E. Preceded by: Nelson (Edition 21 ed.). Philadelphia, PA. 2020. p. 2757. ISBN 978-0-323-56888-3. OCLC 1096283151.CS1 maint: others (link)
External links[]
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- Glomerular diseases
- Disease stubs
- Genitourinary system stubs