Methyllysine

Methyllysine is derivative of the amino acid residue lysine where the sidechain ammonium group has been methylated one or more times.^[1]

Such methylated lysines play an important role in epigenetics; the methylation of specific lysines of certain histones in a nucleosome alters the binding of the surrounding DNA to those histones, which in turn affects the expression of genes on that DNA.^[2]^[3] The binding is affected because the effective radius of the positive charge is increased (methyl groups are larger than the hydrogen atoms they replace), reducing the strongest potential electrostatic attraction with the negatively charged DNA.

It is thought that the methylation of lysine (and arginine) on histone tails does not directly affect their binding to DNA. Rather, such methyl marks recruit other proteins that modulate chromatin structure.^[4]

In Protein Data Bank files, methylated lysines are indicated by the MLY or MLZ acronyms.

Unmethylated lysine
Monomethylated: 6-N-methyllysine
Dimethylated: (6-N,6-N)dimethyllysine
Trimethylated: (6-N,6-N,6-N)trimethyllysine

References[]

^ Hyun, Kwangbeom; Jeon, Jongcheol; Park, Kihyun; Kim, Jaehoon (2017). "Writing, erasing and reading histone lysine methylations". Experimental & Molecular Medicine. 49 (4): e324. doi:10.1038/emm.2017.11. PMC 6130214. PMID 28450737.
^ Ruthenburg AJ, Allis CD, Wysocka J (January 2007). "Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark". Molecular Cell. 25 (1): 15–30. doi:10.1016/j.molcel.2006.12.014. PMID 17218268.
^ Fischle W, Wang Y, Jacobs SA, Kim Y, Allis CD, Khorasanizadeh S (August 2003). "Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains". Genes & Development. 17 (15): 1870–81. doi:10.1101/gad.1110503. PMC 196235. PMID 12897054.
^ Arrowsmith CH, Bountra C, Fish PV, Lee K, Schapira M (April 2012). "Epigenetic protein families: a new frontier for drug discovery". Nature Reviews. Drug Discovery. 11 (5): 384–400. doi:10.1038/nrd3674. PMID 22498752.

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[1] Hyun, Kwangbeom; Jeon, Jongcheol; Park, Kihyun; Kim, Jaehoon (2017). "Writing, erasing and reading histone lysine methylations". Experimental & Molecular Medicine. 49 (4): e324. doi:10.1038/emm.2017.11. PMC 6130214. PMID 28450737.

[2] Ruthenburg AJ, Allis CD, Wysocka J (January 2007). "Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark". Molecular Cell. 25 (1): 15–30. doi:10.1016/j.molcel.2006.12.014. PMID 17218268.

[3] Fischle W, Wang Y, Jacobs SA, Kim Y, Allis CD, Khorasanizadeh S (August 2003). "Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains". Genes & Development. 17 (15): 1870–81. doi:10.1101/gad.1110503. PMC 196235. PMID 12897054.

[4] Arrowsmith CH, Bountra C, Fish PV, Lee K, Schapira M (April 2012). "Epigenetic protein families: a new frontier for drug discovery". Nature Reviews. Drug Discovery. 11 (5): 384–400. doi:10.1038/nrd3674. PMID 22498752.

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