Methylnitronitrosoguanidine

Methylnitronitrosoguanidine^[1]

Names
Preferred IUPAC name N-Methyl-N′-nitro-N-nitrosoguanidine
Other names 1-Methyl-3-nitro-1-nitrosoguanidine N-Methyl-N-nitroso-N′-nitroguanidine
Identifiers
CAS Number	70-25-7 Y
3D model (JSmol)	Interactive image
Abbreviations	MNNG
ChemSpider	6025 N
ECHA InfoCard	100.000.664
KEGG	C14592 Y
PubChem CID	6261
UNII	12H3O2UGSF Y[CAS]
CompTox Dashboard (EPA)	DTXSID2020846
show InChI InChI=1S/C2H5N5O3/c1-6(5-8)2(3)4-7(9)10/h1H3,(H2,3,4) N Key: VZUNGTLZRAYYDE-UHFFFAOYSA-N N InChI=1/C2H5N5O3/c1-6(5-8)2(3)4-7(9)10/h1H3,(H2,3,4) Key: VZUNGTLZRAYYDE-UHFFFAOYAT
show SMILES CN(C(=N[N+](=O)[O-])N)N=O
Properties
Chemical formula	C2H5N5O3
Molar mass	147.09 g/mol
Appearance	Yellow crystals
Melting point	118 °C (244 °F; 391 K) (decomposes)
Solubility in water	reacts violently, slowly hydrolysed
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N  (what is YN ?)
Infobox references

Methylnitronitrosoguanidine (MNNG or MNG) is a biochemical tool used experimentally as a carcinogen and mutagen.^[1] It acts by adding alkyl groups to the O⁶ of guanine and O⁴ of thymine, which can lead to transition mutations between GC and AT. These changes do not cause a heavy distortion in the double helix of DNA and thus are hard to detect by the DNA mismatch repair system.

One of the earliest uses of methylnitronitrosoguanidine was in 1985. A group of scientists tested whether or not the chemical composition of methylnitronitrosoguanidine would directly affect the growth of tumors and cancer cells in rats.^{[citation needed]}

In the experiment, the cancer cells from a Japanese cancer patient was injected into 8 rats. The biochemical tool and showed a decline of cancer cells in a few of the rats' bodies.

In organic chemistry, MNNG is used as a source of diazomethane when reacted with aqueous potassium hydroxide.^{[2][dead link]}

MNNG is a probable human carcinogen listed as an IARC Group 2A carcinogen.^[3]

References[]