Mikael Bols
Mikael Bols | |
---|---|
Born | July 28, 1961 |
Citizenship | Denmark |
Alma mater | Technical University of Denmark |
Known for | Discovery of Isofagomines, the different electronic effects of axial and equatorial OH groups and his work on artificial enzymes |
Scientific career | |
Fields | Organic chemistry |
Institutions | Technical University of Denmark, Queen's University, University of Aarhus, University of Copenhagen |
Doctoral advisor | Inge Lundt |
Mikael Bols (born July 28, 1961) is a synthetic organic chemist who is mainly known for his work on carbohydrates and artificial enzymes.
Early life[]
Mikael Bols was born and grew up in Copenhagen, Denmark. He attended high school (Gentofte Statskole) from 1977-1980, and took a degree as chemical engineer at the Technical University of Denmark from 1980-1985.
Professional career[]
From 1985 to 1988, Bols did PhD with Professor Inge Lundt at the Technical University of Denmark. From 1988-1989, he did a post doc with professor Walter Szarek at Queen's University before joining Leo Pharmaceuticals in 1989. From 1991-1995, he was Ass. Prof. at DTU only interrupted by a visit in the last 6 month of 1994 Gilbert Stork's group at Columbia University. From 1995-2000, he was Assoc. Prof. (Lektor) at University of Aarhus during which period he became Dr. Scient. (1997). From 1998-2000 and from 2004-2006, he was Head of the chemistry department at university of Aarhus. From 2000-2005, he became Lundbeckfondsprofessor and subsequently (2005-2007) ordinary professor. In 2007, he became professor and Head of department of the Department of Chemistry at University of Copenhagen.[1]
Achievements[]
The discovery of isofagomine and related glycosidase inhibitors,[2] the discovery of stereoelectronic substituent effects[3] and superarmed glycosyl donors, the creation of artificial enzymes that cause large rate increases.,[4] and writing the book "Carbohydrate Building Blocks" about using carbohydrates as a chirality source in synthesis.[5]
References[]
- ^ http://www.ki.ku.dk/ansatte/alle/profil/?id=201563
- ^ Bols, M “1-Azasugars, Apparent Transition State Analogs of Equatorial Glycoside Formation/cleavage.” Acc. Chem. Res. 1998 31 1-8.
- ^ Jensen, H. H.; Bols, M. ”Stereoelectronic Substituent Effects.” Acc. Chem. Res. 2006, 39, 259-265.
- ^ Marinescu, L. G.; Bols, M. “Very High Rate Acceleration of Benzyl Alcohol Oxidation by an Artificial Enzyme.” Ang. Chem. Int. Ed. 2006 45 4590-4597.
- ^ Bols, M. "Carbohydrate Building Blocks." John Wiley Science Publishers, New York 1996
- Organic chemists
- 1961 births
- Living people