mir-196 microRNA precursor family

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mir-196 microRNA precursor family
RF00256.jpg
Predicted secondary structure and sequence conservation of mir-196
Identifiers
Symbolmir-196
RfamRF00256
miRBaseMI0000238
miRBase familyMIPF0000031
Other data
RNA typeGene; miRNA
Domain(s)Eukaryota
GOGO:0035195 GO:0035068
SOSO:0001244
PDB structuresPDBe

miR-196 is a non-coding RNA called a microRNA that has been shown to be expressed in humans (MI0000238[permanent dead link], MI0000279) and mice (MI0000552, MI0000553).[1][2] miR-196 appears to be a vertebrate specific microRNA and has now been predicted or experimentally confirmed in a wide range of vertebrate species (MIPF0000031[permanent dead link]). In many species the miRNA appears to be expressed from intergenic regions in HOX gene clusters. The hairpin precursors are predicted based on base pairing and cross-species conservation—their extents are not known. In this case the mature sequence is excised from the 5' arm of the hairpin.

It has been suggested that a rare SNP () that overlaps has-mir-196a2 has been found to be associated with non-small cell lung carcinoma.[3]

Further reading[]

References[]

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  2. ^ Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP (2003). "Vertebrate microRNA genes". Science. 299 (5612): 1540. doi:10.1126/science.1080372. PMID 12624257. S2CID 37750545.
  3. ^ Hu Z, Chen J, Tian T, Zhou X, Gu H, Xu L, Zeng Y, Miao R, Jin G, Ma H, Chen Y, Shen H (2008). "Genetic variants of miRNA sequences and non-small cell lung cancer survival". J Clin Invest. 118 (7): 2600–8. doi:10.1172/JCI34934. PMC 2402113. PMID 18521189.
  4. ^ Zhang XW, Pan SD, Feng YL, Liu JB, Dong J, Zhang YX, Chen JG, Hu ZB, Shen HB (2011). "[Relationship between genetic polymorphism in microRNAs precursor and genetic prediposition of hepatocellular carcinoma]". Zhonghua Yu Fang Yi Xue Za Zhi. 45 (3): 239–43. PMID 21624236.
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  7. ^ Chen C, Zhang Y, Zhang L, Weakley SM, Yao Q (2011). "MicroRNA-196: critical roles and clinical applications in development and cancer". J Cell Mol Med. 15 (1): 14–23. doi:10.1111/j.1582-4934.2010.01219.x. PMC 3276076. PMID 21091634.
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