Miriam Merad

Miram Merad (born in Paris in 1969)^[1] is an Algerian professor in Cancer immunology and the Director of the Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai in New York City, NY. She is the corecipient of the 2018 William B. Coley Award for Distinguished Research in Basic Immunology^[2] and a member of the United States National Academy of Sciences.^[3]

Career[]

Miriam Merad started her medical school at the University of Algiers in 1985 and completed her residency in Paris Diderot University.^[4] She then moved to Stanford University to perform a phD in the laboratory of Edgar Engleman.^[5] She was first recruited to the Icahn School of Medicine at Mount Sinai in 2004 and promoted to the rank of Associate Professor with Tenure in 2007 and to Full Professor in 2010. She obtained an Endowed Chair in Cancer Immunology in 2014.^[6]

Research[]

Miram Merad's early studies were among the first to identify the mechanisms that control the development and functional identity of tissue resident dendritic cells and macrophages. Current research in her lab remains focused on the role dendritic cells and macrophages play within the tumor microenvironment and on how tumors prevent the normal anti-tumor functions of these cells.^[7]

Honors[]

• Vice-President of the International Union of Immunological Societies.^[8]
• Member of the American Society for Clinical Investigation.^[9]
• William B. Coley Award for Distinguished Research in Tumor Immunology^[10]
• Member of the United States National Academy of Sciences.^[11]

Notable publications[]

• Merad, M; Manz, MG; Karsunky, H; Wagers, A; Engleman, EG (2002). "Langerhans cells renew in the skin throughout life under steady-state conditions". Annu Rev Immunol. 3: 1135–1141. doi:10.1038/ni852. PMC 4727838. PMID 12415265.
• Ginhoux, F; Greter, M; Leboeuf, M; Nandi, S; Merad, M (2010). "Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages". Science. 330: 841–845. doi:10.1126/science.1194637. PMC 3719181. PMID 20966214.
• Merad, M; Sather, P; Helft, J; Miller, J; Mortha, A (2013). "The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting". Annu Rev Immunol. 31: 563–604. doi:10.1146/annurev-immunol-020711-074950. PMC 3853342. PMID 23516985.
• Hashimoto, D; Chow, A; Noizat, C; Teo, P; Merad, M (2013). "Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes". Immunity. 38: 792–804. doi:10.1016/j.immuni.2013.04.004.
• Lavin, Y; Winter, D; Blecher-Gonen, R; David, E; Merad, M (2014). "Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment". Cell. 159: 1312–1326. doi:10.1016/j.cell.2014.11.018.

References[]