Mitochondrial pyruvate carrier 2

MPC2
Identifiers
Aliases	MPC2, BRP44, mitochondrial pyruvate carrier 2, SLC54A2
External IDs	OMIM: 614737 MGI: 1917706 HomoloGene: 31675 GeneCards: MPC2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	167,937,072 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	165,308,783 bp
RNA expression pattern
	Top expressed in
	body of stomach; ; testicle; ; liver; ; prostate; ; Right lobe of liver; ; kidney; ; heart;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	pyruvate transmembrane transporter activity;
Cellular component	integral component of membrane; mitochondrial inner membrane; membrane; mitochondrion; nucleus; integral component of mitochondrial inner membrane;
Biological process	mitochondrial acetyl-CoA biosynthetic process from pyruvate; positive regulation of insulin secretion involved in cellular response to glucose stimulus; mitochondrial pyruvate transmembrane transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	25874
	70456
	ENSG00000143158
	ENSMUSG00000026568
	O95563; Q5R3B4
	Q9D023
	NM_001143674; NM_015415
	NM_027430
	NP_001137146; NP_056230
	NP_081706
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial pyruvate carrier 2 (MPC2) also known as brain protein 44 (BRP44) is a protein that in humans is encoded by the MPC2 gene.^[5]^[6]^[7] It is part of the (MPC) protein family. ^[8] This protein is involved in transport of pyruvate across the inner membrane of mitochondria in preparation for the pyruvate dehydrogenase reaction. ^[9]

Interactive pathway map[]

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Glycolysis and Gluconeogenesis edit]]

Glycolysis and Gluconeogenesis edit

^ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143158 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026568 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
^ Tsou AP, Lai C, Danielson P, Noonan DJ, Sutcliffe JG (Dec 1986). "Structural characterization of a heterogeneous family of rat brain mRNAs". Mol Cell Biol. 6 (3): 768–78. doi:10.1128/mcb.6.3.768. PMC 367577. PMID 3022128.
^ "Entrez Gene: BRP44 brain protein 44".
^ https://www.uniprot.org/uniprot/?query=family:%22mitochondrial+pyruvate+carrier+%28MPC%29+%28TC+2.A.105%29+family%22
^ "QuickGO".

Further reading[]

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by .

[WikiPathways-10] The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143158 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026568 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11230166-5] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[pmid3022128-6] Tsou AP, Lai C, Danielson P, Noonan DJ, Sutcliffe JG (Dec 1986). "Structural characterization of a heterogeneous family of rat brain mRNAs". Mol Cell Biol. 6 (3): 768–78. doi:10.1128/mcb.6.3.768. PMC 367577. PMID 3022128.

[entrez-7] "Entrez Gene: BRP44 brain protein 44".

[8] ttps://www.uniprot.org/uniprot/?query=family:%22mitochondrial+pyruvate+carrier+%28MPC%29+%28TC+2.A.105%29+family%22

[9] "QuickGO".

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