Motile sperm domain containing 3 is a protein that in humans is encoded by the MOSPD3 gene.[5]
Function[]
This gene encodes a multi-pass membrane protein with a major sperm protein (MSP) domain. The deletion of a similar mouse gene is associated with defective cardiac development and neonatal lethality. Alternate transcriptional splice variants, encoding different isoforms, have been described.
Pall GS, Wallis J, Axton R, Brownstein DG, Gautier P, Buerger K, Mulford C, Mullins JJ, Forrester LM (December 2004). "A novel transmembrane MSP-containing protein that plays a role in right ventricle development". Genomics. 84 (6): 1051–9. doi:10.1016/j.ygeno.2004.08.017. PMID15533722.
Cabukusta B, Berlin I, van Elsland DM, Forkink I, Spits M, de Jong AW, Akkermans JJ, Wijdeven RH, Janssen GM, van Veelen PA, Neefjes J (December 2020). "Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs". Cell Reports. 33 (10). doi:10.1016/j.celrep.2020.108475. PMID33296653.