Multivesicular release

Multivesicular release (MVR) is the phenomenon by which individual chemical synapses, forming the junction between neurons, is mediated by multiple releasable vesicles of neurotransmitter.^[1] In neuroscience, it is a subject of debate whether one or many vesicles are released per action potential.^[2]

Examples[]

In the mammalian brain, MVR has been shown to be common in CA1 pyramidal cells and Schaffer collateral cells.^[2] It has also been proposed^[3] and then refuted^[4] at the ribbon synapses formed between inner hair cell and spiral ganglion neurons.^[5] Recent evidence points to a possibility of MVR at neocortical connections of the somatosensory cortex.^[6]

References[]

^ Tong, G; Jahr, CE (January 1994). "Multivesicular release from excitatory synapses of cultured hippocampal neurons". Neuron. 12 (1): 51–9. doi:10.1016/0896-6273(94)90151-1. PMID 7507341.
^ ^a ^b Christie, JM; Jahr, CE (4 January 2006). "Multivesicular release at Schaffer collateral-CA1 hippocampal synapses". The Journal of Neuroscience. 26 (1): 210–6. doi:10.1523/jneurosci.4307-05.2006. PMC 2670931. PMID 16399689.
^ Glowatzki, E; Fuchs, PA (February 2002). "Transmitter release at the hair cell ribbon synapse". Nature Neuroscience. 5 (2): 147–54. doi:10.1038/nn796. PMID 11802170.
^ Chapochnikov NM, Takago H, Huang CH, Pangršič T, Khimich D, Neef J, Auge E, Göttfert F, Hell SW, Wichmann C, Wolf F, Moser T (2014). "Uniquantal release through a dynamic fusion pore is a candidate mechanism of hair cell exocytosis". Neuron. 83 (6): 1389–403. doi:10.1016/j.neuron.2014.08.003. PMID 25199706.
^ Fuchs, PA (1 July 2005). "Time and intensity coding at the hair cell's ribbon synapse". The Journal of Physiology. 566 (Pt 1): 7–12. doi:10.1113/jphysiol.2004.082214. PMC 1464726. PMID 15845587.
^ Huang, CH; Bao, J; Sakaba, T (8 September 2010). "Multivesicular release differentiates the reliability of synaptic transmission between the visual cortex and the somatosensory cortex". The Journal of Neuroscience. 30 (36): 11994–2004. doi:10.1523/jneurosci.2381-10.2010. PMC 6633560. PMID 20826663.

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[1] Tong, G; Jahr, CE (January 1994). "Multivesicular release from excitatory synapses of cultured hippocampal neurons". Neuron. 12 (1): 51–9. doi:10.1016/0896-6273(94)90151-1. PMID 7507341.

[christie-2] Christie, JM; Jahr, CE (4 January 2006). "Multivesicular release at Schaffer collateral-CA1 hippocampal synapses". The Journal of Neuroscience. 26 (1): 210–6. doi:10.1523/jneurosci.4307-05.2006. PMC 2670931. PMID 16399689.

[3] Glowatzki, E; Fuchs, PA (February 2002). "Transmitter release at the hair cell ribbon synapse". Nature Neuroscience. 5 (2): 147–54. doi:10.1038/nn796. PMID 11802170.

[4] Chapochnikov NM, Takago H, Huang CH, Pangršič T, Khimich D, Neef J, Auge E, Göttfert F, Hell SW, Wichmann C, Wolf F, Moser T (2014). "Uniquantal release through a dynamic fusion pore is a candidate mechanism of hair cell exocytosis". Neuron. 83 (6): 1389–403. doi:10.1016/j.neuron.2014.08.003. PMID 25199706.

[5] Fuchs, PA (1 July 2005). "Time and intensity coding at the hair cell's ribbon synapse". The Journal of Physiology. 566 (Pt 1): 7–12. doi:10.1113/jphysiol.2004.082214. PMC 1464726. PMID 15845587.

[6] Huang, CH; Bao, J; Sakaba, T (8 September 2010). "Multivesicular release differentiates the reliability of synaptic transmission between the visual cortex and the somatosensory cortex". The Journal of Neuroscience. 30 (36): 11994–2004. doi:10.1523/jneurosci.2381-10.2010. PMC 6633560. PMID 20826663.

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