NLRX1

NLRX1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3UN9
Identifiers
Aliases	NLRX1, CLR11.3, DLNB26, NOD26, NOD5, NOD9, NLR family member X1
External IDs	OMIM: 611947 MGI: 2429611 HomoloGene: 11623 GeneCards: NLRX1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	119,184,016 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	44,179,896 bp
RNA expression pattern
	Top expressed in
	esophagus; ; left ventricle; ; muscle of leg; ; stomach; ; quadriceps femoris muscle; ; squamous epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; GO:0001948 protein binding; ATP binding;
Cellular component	mitochondrial outer membrane; membrane; mitochondrion; plasma membrane; cell junction; cytoplasm;
Biological process	negative regulation of interleukin-6 production; negative regulation of type I interferon production; GO:0022415 viral process; negative regulation of inflammatory response; negative regulation of interferon-beta production; negative regulation of RIG-I signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB signaling; immune system process; negative regulation of innate immune response; innate immune response; GO:0007243 intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	79671
	270151
	ENSG00000160703
	ENSMUSG00000032109
	Q86UT6
	Q3TL44
	NM_001282143; NM_001282144; NM_001282358; NM_024618; NM_170722
	NM_001163742; NM_001163743; NM_178420
	NP_001269072; NP_001269073; NP_001269287; NP_078894
	NP_001157214; NP_001157215; NP_848507
	Wikidata
View/Edit Human	View/Edit Mouse

NLRX1 or NLR family member X1, short for nucleotide-binding oligomerization domain, leucine rich repeat containing X1 is a protein that in humans is encoded by the NLRX1 gene.^[5]^[6] It is also known as NOD-like receptor X1, NLR family, X1, NOD5, NOD9, and CLR11.3, and is a member of the NOD-like receptor family of pattern recognition receptors.

Function[]

NLRX1 is an intracellular protein that plays a role in the immune system. NLRX1 has been proposed to affect innate immunity to viruses by interfering with the mitochondrial antiviral signaling protein (MAVS)/retinoic-acid-inducible gene I (RIG-I) mitochondrial antiviral pathway.,^[7] although this was recently questioned.^[8]^[9]

NLRX1 also plays a role in host immunity during bacterial infections, such as Chlamydia trachomatis and Helicobacter pylori, by regulating bacterial burden and inflammation in mononuclear phagocytes. Mechanisms underlying the modulation of NLRX1 are not well characterized, however computational modeling predictions suggest that levels of NLRX1 may be controlled by negative feedback circuits induced early after infection.^[10]^[11]^[12]

Structure[]

NLRX1 has a unique protein structure composed of 3 protein domains: an N-terminal effector domain containing a mitochondrion localization signal; a central NACHT domain; a C-terminal leucine-rich repeat (LRR) domain.^[13]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160703 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032109 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: NLR family member X1".
^ Inohara N, Nuñez G (May 2003). "NODs: intracellular proteins involved in inflammation and apoptosis". Nature Reviews. Immunology. 3 (5): 371–82. doi:10.1038/nri1086. PMID 12766759. S2CID 8088987.
^ O'Neill LA (Apr 2008). "Innate immunity: squelching anti-viral signalling with NLRX1". Current Biology. 18 (7): R302-4. doi:10.1016/j.cub.2008.02.021. PMID 18397740. S2CID 18188728.
^ Rebsamen M, Vazquez J, Tardivel A, Guarda G, Curran J, Tschopp J (Aug 2011). "NLRX1/NOD5 deficiency does not affect MAVS signalling". Cell Death and Differentiation. 18 (8): 1387. doi:10.1038/cdd.2011.64. PMC 3172102. PMID 21617692.
^ Soares F, Tattoli I, Wortzman ME, Arnoult D, Philpott DJ, Girardin SE (2013). "NLRX1 does not inhibit MAVS-dependent antiviral signalling". Innate Immunity. 19 (4): 438–48. doi:10.1177/1753425912467383. PMID 23212541. S2CID 20642957.
^ Castaño-Rodríguez N, Kaakoush NO, Goh KL, Fock KM, Mitchell HM (2014-01-01). "The NOD-like receptor signalling pathway in Helicobacter pylori infection and related gastric cancer: a case-control study and gene expression analyses". PLOS ONE. 9 (6): e98899. Bibcode:2014PLoSO...998899C. doi:10.1371/journal.pone.0098899. PMC 4047072. PMID 24901306.
^ Philipson CW, Bassaganya-Riera J, Viladomiu M, Kronsteiner B, Abedi V, Hoops S, Michalak P, Kang L, Girardin SE, Hontecillas R (2015-01-01). "Modeling the Regulatory Mechanisms by Which NLRX1 Modulates Innate Immune Responses to Helicobacter pylori Infection". PLOS ONE. 10 (9): e0137839. Bibcode:2015PLoSO..1037839P. doi:10.1371/journal.pone.0137839. PMC 4569576. PMID 26367386.
^ Abdul-Sater AA, Saïd-Sadier N, Lam VM, Singh B, Pettengill MA, Soares F, Tattoli I, Lipinski S, Girardin SE, Rosenstiel P, Ojcius DM (Dec 2010). "Enhancement of reactive oxygen species production and chlamydial infection by the mitochondrial Nod-like family member NLRX1". The Journal of Biological Chemistry. 285 (53): 41637–45. doi:10.1074/jbc.M110.137885. PMC 3009891. PMID 20959452.
^ Meylan E, Tschopp J (Mar 2008). "NLRX1: friend or foe?". EMBO Reports. 9 (3): 243–5. doi:10.1038/embor.2008.23. PMC 2267384. PMID 18311173.

Further reading[]

Moore CB, Bergstralh DT, Duncan JA, Lei Y, Morrison TE, Zimmermann AG, Accavitti-Loper MA, Madden VJ, Sun L, Ye Z, Lich JD, Heise MT, Chen Z, Ting JP (Jan 2008). "NLRX1 is a regulator of mitochondrial antiviral immunity". Nature. 451 (7178): 573–7. Bibcode:2008Natur.451..573M. doi:10.1038/nature06501. PMID 18200010.
Tattoli I, Carneiro LA, Jéhanno M, Magalhaes JG, Shu Y, Philpott DJ, Arnoult D, Girardin SE (Mar 2008). "NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production". EMBO Reports. 9 (3): 293–300. doi:10.1038/sj.embor.7401161. PMC 2267388. PMID 18219313.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Arnoult D, Soares F, Tattoli I, Castanier C, Philpott DJ, Girardin SE (Sep 2009). "An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix". Journal of Cell Science. 122 (Pt 17): 3161–8. doi:10.1242/jcs.051193. PMC 2871076. PMID 19692591.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1��2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160703 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032109 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: NLR family member X1".

[pmid12766759-6] Inohara N, Nuñez G (May 2003). "NODs: intracellular proteins involved in inflammation and apoptosis". Nature Reviews. Immunology. 3 (5): 371–82. doi:10.1038/nri1086. PMID 12766759. S2CID 8088987.

[pmid18397740-7] O'Neill LA (Apr 2008). "Innate immunity: squelching anti-viral signalling with NLRX1". Current Biology. 18 (7): R302-4. doi:10.1016/j.cub.2008.02.021. PMID 18397740. S2CID 18188728.

[8] Rebsamen M, Vazquez J, Tardivel A, Guarda G, Curran J, Tschopp J (Aug 2011). "NLRX1/NOD5 deficiency does not affect MAVS signalling". Cell Death and Differentiation. 18 (8): 1387. doi:10.1038/cdd.2011.64. PMC 3172102. PMID 21617692.

[9] Soares F, Tattoli I, Wortzman ME, Arnoult D, Philpott DJ, Girardin SE (2013). "NLRX1 does not inhibit MAVS-dependent antiviral signalling". Innate Immunity. 19 (4): 438–48. doi:10.1177/1753425912467383. PMID 23212541. S2CID 20642957.

[10] Castaño-Rodríguez N, Kaakoush NO, Goh KL, Fock KM, Mitchell HM (2014-01-01). "The NOD-like receptor signalling pathway in Helicobacter pylori infection and related gastric cancer: a case-control study and gene expression analyses". PLOS ONE. 9 (6): e98899. Bibcode:2014PLoSO...998899C. doi:10.1371/journal.pone.0098899. PMC 4047072. PMID 24901306.

[11] Philipson CW, Bassaganya-Riera J, Viladomiu M, Kronsteiner B, Abedi V, Hoops S, Michalak P, Kang L, Girardin SE, Hontecillas R (2015-01-01). "Modeling the Regulatory Mechanisms by Which NLRX1 Modulates Innate Immune Responses to Helicobacter pylori Infection". PLOS ONE. 10 (9): e0137839. Bibcode:2015PLoSO..1037839P. doi:10.1371/journal.pone.0137839. PMC 4569576. PMID 26367386.

[12] Abdul-Sater AA, Saïd-Sadier N, Lam VM, Singh B, Pettengill MA, Soares F, Tattoli I, Lipinski S, Girardin SE, Rosenstiel P, Ojcius DM (Dec 2010). "Enhancement of reactive oxygen species production and chlamydial infection by the mitochondrial Nod-like family member NLRX1". The Journal of Biological Chemistry. 285 (53): 41637–45. doi:10.1074/jbc.M110.137885. PMC 3009891. PMID 20959452.

[pmid18311173-13] Meylan E, Tschopp J (Mar 2008). "NLRX1: friend or foe?". EMBO Reports. 9 (3): 243–5. doi:10.1038/embor.2008.23. PMC 2267384. PMID 18311173.

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v t NOD-like receptor family
CARD domain containing	NOD1/NLRC1 NOD2/NLRC2 NLRC3 NLRC4 NLRC5
Pyrin domain containing	NLRP1 NLRP2 NLRP3 NLRP4 NLRP5 NLRP6 NLRP7 NLRP8 NLRP9 NLRP10 NLRP11 NLRP12 NLRP13 NLRP14
Apoptosis inhibitory protein	NAIP
Family member X1	NLRX1