NPLOC4

NPLOC4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PJH
Identifiers
Aliases	NPLOC4, NPL4, NPL4 homolog, ubiquitin recognition factor
External IDs	OMIM: 606590 MGI: 2679787 HomoloGene: 5403 GeneCards: NPLOC4
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 81,556,887 bp[1] End 81,648,465 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 120,271,196 bp[2] End 120,328,534 bp[2]
RNA expression pattern Bgee Top expressed in testicle gastrocnemius muscle stomach muscle of leg sural nerve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin binding GO:0001948 protein binding metal ion binding ubiquitin protein ligase binding Cellular component cytoplasm cytosol nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum nucleus UFD1-NPL4 complex nucleoplasm VCP-NPL4-UFD1 AAA ATPase complex Biological process error-free translesion synthesis retrograde protein transport, ER to cytosol Golgi organization ubiquitin-dependent ERAD pathway proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of type I interferon production negative regulation of RIG-I signaling pathway ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55666	217365
Ensembl	ENSG00000182446	ENSMUSG00000039703
UniProt	Q8TAT6	P60670
RefSeq (mRNA)	NM_017921 NM_001369698	NM_001195023 NM_199469
RefSeq (protein)	NP_060391 NP_001356627 NP_060391.2	NP_001181952 NP_955763
Location (UCSC)	Chr 17: 81.56 – 81.65 Mb	Chr 11: 120.27 ��� 120.33 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Nuclear protein localization protein 4 homolog is a protein that in humans is encoded by the NPLOC4 gene.^[5][6][7]

Model organisms[]

Model organisms have been used in the study of NPLOC4 function. A conditional knockout mouse line, called Nploc4^{tm1a(EUCOMM)Wtsi[12][13]} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.^[14][15][16]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[10][17] Twenty six tests were carried out and two phenotypes were reported. No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; no significant abnormalities were observed in these animals.^[10]

Interactions[]

NPLOC4 has been shown to interact with UFD1L.^[5][18]

References[]

Further reading[]

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