Nanos 3′ UTR translation control element

Nanos 3′ UTR translation control element
Nanos 3′ UTR translation control element
	Predicted secondary structure and sequence conservation of nos_TCE
Identifiers
Symbol	nos_TCE
Rfam	RF00161
Other data
RNA type	Cis-reg
Domain(s)	Eukaryota
GO	GO:0008595 GO:0017148 GO:0005515
SO	SO:0000205
PDB structures	PDBe

Nanos 3′ UTR translation control element is a cis-regulatory element in the 3′ untranslated region (3′ UTR) of the messenger RNA which encodes the Nanos protein. The Nanos protein in Drosophila is required for correct morphogenesis (anterior/posterior patterning) in the Drosophila embryo. Translation of the Nanos mRNA is repressed in the bulk cytoplasm and activated in the posterior region. The translation control element (TCE) in the 3'UTR forms a Y-shaped secondary structure, part of which is recognised by the Smaug protein and leads to translational repression.^[1]

References[]

^ Crucs S, Chatterjee S, Gavis ER (2000). "Overlapping but distinct RNA elements control repression and activation of nanos translation". Mol. Cell. 5 (3): 457–467. doi:10.1016/S1097-2765(00)80440-2. PMID 10882131.

External links[]

Page for Nanos 3′ UTR translation control element at Rfam

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[pmid10882131-1] Crucs S, Chatterjee S, Gavis ER (2000). "Overlapping but distinct RNA elements control repression and activation of nanos translation". Mol. Cell. 5 (3): 457–467. doi:10.1016/S1097-2765(00)80440-2. PMID 10882131.

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