Nektarios Tavernarakis

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Nektarios Tavernarakis
Νεκτάριος Νικολάου Ταβερναράκης
Nektarios Tavernarakis 1.jpg
Nektarios Tavernarakis at the Foundation for Research & Technology in Heraklion Crete, Greece (ca. 2020)
Born (1967-05-02) May 2, 1967 (age 54)
NationalityGreek Flag of Greece.svg
CitizenshipGreek Flag of Greece.svg
EducationBSc: Biology, Aristotle University of Thessaloniki (1989)
PhD: Molecular Genetics, University of Crete (1995)
Alma materAristotle University of Thessaloniki, Thessaloniki, Greece
Known forAgeing, Necrosis, Neurodegeneration
AwardsEuropean Research Council (ERC) Advanced Investigator grant award (twice)
European Research Council (ERC) Proof of Concept grant award
EMBO Young Investigator award
Academy of Athens BioMedical Research Award
Alexander von Humboldt Friedrich Wilhelm Bessel research award
Galien Scientific Research Award
Helmholtz International Fellow Award
Human Frontier Science Program (HFSP) long-term postdoctoral fellowship
Bodossaki Foundation Scientific Prize for Medicine and Biology
Foundation for Research and Technology Research Excellence award
Empeirikeion Foundation Academic Excellence Prize
Scientific career
FieldsBiology, Cell Biology, Ageing, Neurodegeneration, Systems Biology, Metabolism
InstitutionsFoundation for Research & Technology – Hellas (FORTH), Institute of Molecular Biology and Biotechnology (IMBB)
University of Crete, Medical School
ThesisThe yeast transcriptional activator Gcn4p: Expression and function (1995)
Websitewww.elegans.gr
Notes
Member of the Academy of Athens, the German National Academy of Sciences-Leopoldina, the EMBO, Academia Europaea, the European Academy of Sciences and Arts, the EIT Governing Board & the ERC Scientific Council, Fellow of the AAAS

Nektarios N. Tavernarakis (Greek: Νεκτάριος Ν. Ταβερναράκης) is a bioscientist, who studies Ageing, Cell death, and Neurodegeneration.[1][2] He is currently Professor of Molecular Systems Biology at the Medical School of the University of Crete, and the Chairman of the Board of Directors at the Foundation for Research and Technology, in Heraklion, Crete, Greece. He is also the founder and Director of the Graduate Program in Bioinformatics of the University of Crete Medical School, and has served as Director of the Institute of Molecular Biology and Biotechnology, where he is heading the Neurogenetics and Ageing laboratory. In 2020, he was elected Vice President of the European Research Council (ERC).[3]

Biographical information[]

Nektarios Tavernarakis completed his undergraduate studies at the Department of Biology of the Aristotle University, in Thessaloniki, Greece, and obtained his PhD degree from the Department of Biology of the University of Crete, in Heraklion, Greece. He trained as a postdoctoral researcher at the Department of Molecular Biology & Biochemistry of Rutgers University in New Jersey, USA. He has made notable contributions relevant to cell death, neurodegeneration and ageing, documented in the scientific literature.[4][5]

In 2020, Nektarios Tavernarakis was elected Vice President of the European Research Council (ERC).[6] He is a member of the European Institute of Innovation and Technology (EIT) Governing Board,[7] the European Molecular Biology Organization (EMBO),[8] Academia Europaea[9] and the European Academy of Sciences and Arts.[10] He is also a corresponding member of the Academy of Athens.[11]

His work has received several prominent awards and scientific prizes, including two European Research Council (ERC) Advanced Investigator grant awards (in 2008 and 2016),[12][13] a European Research Council (ERC) Proof of Concept grant award,[14] the EMBO Young Investigator award, the International Human Frontier Science Program (HFSP) long-term postdoctoral fellowship, the BioMedical Research Award of the Academy of Athens, the Valergakis Post-Graduate Award of the Hellenic University Club of New York, the Galien Scientific Research Award,[15] the Helmholtz International Fellow Award,[16] the Bodossaki Foundation Scientific Prize for Medicine and Biology, the Alexander von Humboldt Foundation, Friedrich Wilhelm Bessel research award, the Research Excellence award of the Foundation for Research and Technology, and the Empeirikeion Foundation Academic Excellence Prize, among others.

Research and scientific achievements[]

Nektarios Tavernarakis has contributed to the elucidation of the molecular mechanisms of necrotic cell death and neurodegeneration, the interplay between cellular metabolism and ageing, the mechanisms of sensory transduction and integration by the nervous system.[17][18] He has also contributed towards the development of novel genetic tools for biomedical research, including an RNA interference (RNAi) method that allows efficient knockdown of neuronal genes.[19] His PhD Thesis research focused on the expression and function of key stress response transcriptional activators in the yeast Saccharomyces cerevisiae, and provided original insights on the regulation of these activators by nutrient limitation, and the role of DNA in determining interactions between transcription factors and co-factors.[20] His laboratory at IMBB was the first to commence Caenorhabditis elegans research in Greece. Among the notable discoveries of his team are the sophisticated molecular mechanisms, by which diverse physiological signals are integrated to modulate cellular mitochondrial content,[21] protein synthesis,[22][23] and energy homeostasis during ageing.[24] These studies revealed intricate signaling pathways that coordinate mitophagy and mitochondrial biogenesis, to determine the number of mitochondria in cells, under stress and during ageing.[25][26] Work from his lab implicated autophagy,[27] lysosomal function,[28][29] endocytosis,[30] intracellular calcium homeostasis[31] and specific proteolytic enzymes[32] as major contributors to necrosis and neurodegeneration. His group developed, for the first time, experimental heat stroke models; and identified mechanisms protecting against heat cytotoxicity and other necrotic insults.[33] He has isolated and characterized specific ion channels, involved in proprioception and coordinated locomotion,[34] in dopaminergic signalling and associative learning.[35] His team was also the first to delineate the role of autophagy in the regulation of synaptic plasticity and behaviour under nutrient deprivation and stress.[36][37]

Selected awards and distinctions[]

Selected publications[]

References[]

  1. ^ Search Results for author Tavernarakis N on PubMed.
  2. ^ "Nektarios Tavernarakis - Google Scholar". Retrieved 2015-11-23.
  3. ^ Composition of the ERC Scientific Council on the site of ERC: https://erc.europa.eu/about-erc/erc-president-and-scientific-council
  4. ^ "Nektarios Tavernarakis B-9684-2013". ResearcherID.com. 2014-01-02. Retrieved 2015-11-23.
  5. ^ "Nektarios Tavernarakis (0000-0002-5253-1466) - ORCID | Connecting Research and Researchers". ORCID. Retrieved 2015-11-23.
  6. ^ Composition of the ERC Scientific Council on the site of ERC: https://erc.europa.eu/about-erc/erc-president-and-scientific-council
  7. ^ Jump up to: a b "European Commission: 4 members to EIT Governing Board". eit.europa.eu.
  8. ^ Jump up to: a b "EMBO members". Embo.org. Retrieved 2015-11-23.
  9. ^ Jump up to: a b "Academy of Europe: Tavernarakis Nektarios". Ae-info.org. Retrieved 2015-11-23.
  10. ^ Jump up to: a b "European Academy of Sciences and Arts members". euro-acad.eu.
  11. ^ Jump up to: a b "Εκλογή του Καθηγητή της Ιατρικής Σχολής του Πανεπιστημίου Κρήτης κ. Νεκτάριου Ταβερναράκη ως αντεπιστέλλοντος μέλους της Ακαδημίας Αθηνών στην Έδρα της Νευροβιολογίας-Βιολογίας της Γήρανσης". academyofathens.gr.
  12. ^ Jump up to: a b "European Commission : CORDIS : Projects & Results Service : Molecular Basis of Neuronal Ageing". Cordis.europa.eu. Retrieved 2015-11-23.
  13. ^ Jump up to: a b "ERC Advanced Grants: €647 million from the EU to 277 senior research leaders" (PDF). erc.europa.eu. Retrieved 2016-05-25.
  14. ^ "ERC Proof of Concept Grants: 45 ERC grantees receive top-up innovation funding" (PDF). erc.europa.eu. Retrieved 2016-09-30.
  15. ^ Jump up to: a b "Prix Galien: Galien Scientific Research Award". prixgalien.gr. Retrieved 2017-04-06.
  16. ^ Jump up to: a b "Helmholtz International Fellow Award". helmholtz.de.
  17. ^ pubmeddev. "Tavernarakis N - PubMed - NCBI". www.ncbi.nlm.nih.gov.
  18. ^ "Nektarios Tavernarakis - Google Scholar". scholar.google.com.
  19. ^ Tavernarakis, Nektarios; Wang, Shi L.; Dorovkov, Maxim; Ryazanov, Alexey; Driscoll, Monica (1 February 2000). "Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes". Nature Genetics. 24 (2): 180–183. doi:10.1038/72850. PMID 10655066. S2CID 24334113.
  20. ^ "Διατριβή: Ο ΜΕΤΑΓΡΑΦΙΚΟΣ ΕΝΕΡΓΟΠΟΙΗΤΗΣ GCNH: ΜΕΛΕΤΗ ΤΗΣ ΕΚΦΡΑΣΗΣ ΚΑΙ ΤΟΥ ΜΗΧΑΝΙΣΜΟΥ ΛΕΙΤΟΥΡΓΙΑΣ ΤΟΥ - Κωδικός: 3450". thesis.ekt.gr.
  21. ^ Palikaras, K.; Lionaki, E.; Tavernarakis, N. (1 September 2015). "Balancing mitochondrial biogenesis and mitophagy to maintain energy metabolism homeostasis". Cell Death & Differentiation. 22 (9): 1399–1401. doi:10.1038/cdd.2015.86. PMC 4532782. PMID 26256515.
  22. ^ Syntichaki, Popi; Troulinaki, Kostoula; Tavernarakis, Nektarios (22 February 2007). "eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans". Nature. 445 (7130): 922–926. Bibcode:2007Natur.445..922S. doi:10.1038/nature05603. PMID 17277769. S2CID 4323753.
  23. ^ Rieckher M, Markaki M, Princz A, Schumacher B, Tavernarakis N (2018). "Maintenance of proteostasis by P body-mediated regulation of eIF4E availability during ageing in Caenorhabditis elegans". Cell Reports. 25 (1): 199–211. doi:10.1016/j.celrep.2018.09.009. PMC 6180348. PMID 30282029.
  24. ^ Artal-Sanz, Marta; Tavernarakis, Nektarios (8 October 2009). "Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans". Nature. 461 (7265): 793–797. Bibcode:2009Natur.461..793A. doi:10.1038/nature08466. PMID 19812672. S2CID 4429858.
  25. ^ Palikaras, Konstantinos; Lionaki, Eirini; Tavernarakis, Nektarios (28 May 2015). "Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans". Nature. 521 (7553): 525–528. Bibcode:2015Natur.521..525P. doi:10.1038/nature14300. PMID 25896323. S2CID 4451530.
  26. ^ Palikaras K, Lionaki E, Tavernarakis N (2018). "Mechanisms of mitophagy in cellular homeostasis, physiology and pathology". Nature Cell Biology. 20 (9): 1013–1022. doi:10.1038/s41556-018-0176-2. PMID 30154567. S2CID 52113802.
  27. ^ Samara, C.; Syntichaki, P.; Tavernarakis, N. (28 September 2007). "Autophagy is required for necrotic cell death in Caenorhabditis elegans". Cell Death & Differentiation. 15 (1): 105–112. doi:10.1038/sj.cdd.4402231. PMID 17901876.
  28. ^ Artal-Sanz, Marta; Samara, Chrysanthi; Syntichaki, Popi; Tavernarakis, Nektarios (24 April 2006). "Lysosomal biogenesis and function is critical for necrotic cell death in Caenorhabditis elegans". J Cell Biol. 173 (2): 231–239. doi:10.1083/jcb.200511103. PMC 2063814. PMID 16636145.
  29. ^ Syntichaki, Popi; Samara, Chrysanthi; Tavernarakis, Nektarios (12 July 2005). "The Vacuolar H+-ATPase Mediates Intracellular Acidification Required for Neurodegeneration in C. elegans". Current Biology. 15 (13): 1249–1254. doi:10.1016/j.cub.2005.05.057. PMID 16005300. S2CID 16500500.
  30. ^ Troulinaki, Kostoula; Tavernarakis, Nektarios (1 February 2012). "Endocytosis and intracellular trafficking contribute to necrotic neurodegeneration in C. elegans". The EMBO Journal. 31 (3): 654–666. doi:10.1038/emboj.2011.447. PMC 3273398. PMID 22157748.
  31. ^ Xu, Keli; Tavernarakis, Nektarios; Driscoll, Monica (27 September 2001). "Necrotic Cell Death in C. elegans Requires the Function of Calreticulin and Regulators of Ca2+ Release from the Endoplasmic Reticulum". Neuron. 31 (6): 957–971. doi:10.1016/S0896-6273(01)00432-9. PMID 11580896. S2CID 14026924.
  32. ^ Syntichaki, Popi; Xu, Keli; Driscoll, Monica; Tavernarakis, Nektarios (31 October 2002). "Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans". Nature. 419 (6910): 939–944. Bibcode:2002Natur.419..939S. doi:10.1038/nature01108. PMID 12410314. S2CID 4317198.
  33. ^ Kourtis, Nikos; Nikoletopoulou, Vassiliki; Tavernarakis, Nektarios (11 October 2012). "Small heat-shock proteins protect from heat-stroke-associated neurodegeneration". Nature. 490 (7419): 213–218. Bibcode:2012Natur.490..213K. doi:10.1038/nature11417. PMID 22972192. S2CID 4404066.
  34. ^ Tavernarakis, Nektarios; Shreffler, Wayne; Wang, Shiliang; Driscoll, Monica (1 January 1997). "unc-8, a DEG/ENaC Family Member, Encodes a Subunit of a Candidate Mechanically Gated Channel That Modulates C. elegans Locomotion". Neuron. 18 (1): 107–119. doi:10.1016/S0896-6273(01)80050-7. PMID 9010209. S2CID 16667697.
  35. ^ Voglis, Giannis; Tavernarakis, Nektarios (17 December 2008). "A synaptic DEG/ENaC ion channel mediates learning in C. elegans by facilitating dopamine signalling". The EMBO Journal. 27 (24): 3288–3299. doi:10.1038/emboj.2008.252. PMC 2609744. PMID 19037257.
  36. ^ Nikoletopoulou V, Sidiropoulou K, Kallergi E, Dalezios Y, Tavernarakis N (2017). "Modulation of autophagy by BDNF underlies synaptic plasticity". Cell Metabolism. 26 (1): 230–42. doi:10.1016/j.cmet.2017.06.005. PMID 28683289.
  37. ^ Nikoletopoulou V, Tavernarakis N (2018). "Regulation and roles of autophagy at synapses". Trends in Cell Biology. 28 (8): 230–42 646–661. doi:10.1016/j.tcb.2018.03.006. PMID 29731196.
  38. ^ "AAAS Announces Leading Scientists Elected as 2020 Fellows". aaas.org.
  39. ^ "Andrzej Jajszczyk and Nektarios Tavernarakis elected new ERC Vice Presidents". erc.europa.eu.
  40. ^ "Prof. Dr. Nektarios Tavernarakis". leopoldina.org.
  41. ^ "Education Business Award". educationbusinessawards.gr. Archived from the original on 2017-05-16. Retrieved 2017-05-17.
  42. ^ "ERC Scientific council". erc.europa.eu.
  43. ^ "Fondation Santé". Fondationsante.org. 2015-10-01. Retrieved 2015-11-23.
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  45. ^ "Alexander von Humboldt-Foundation - Researching the Network". Humboldt-foundation.de. Retrieved 2015-11-23.
  46. ^ "Nektarios Tavernarakis: Faculty Member in Cellular Death & Stress Responses - F1000Prime". F1000.com. 2006-07-18. Retrieved 2015-11-23.
  47. ^ "Scientific Awards | Bodossaki Foundation" (in Greek). Bodossaki.gr. Archived from the original on 2015-11-24. Retrieved 2015-11-23.
  48. ^ "Search the YIP database". 194.94.44.233. Archived from the original on 2015-11-23. Retrieved 2015-11-23.
  49. ^ "Awards Archive | Human Frontier Science Program". Hfsp.org. Archived from the original on 2011-02-19. Retrieved 2015-11-23.

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