Nuclear groove

Nuclear grooves (arrows indicate one of them) in papillary thyroid cancer.

A nuclear groove is an invagination of the nuclear envelope, in the longitudinal axis.^[1] It can be present in:

• Thyroid neoplasms: It is a characteristic feature of papillary thyroid carcinoma, but has also been seen in other types of thyroid neoplasms, as well as in non-neoplastic thyroid lesions.^[1]
• Ovarian tumors including Brenner tumors, , and .^[1]
• Breast carcinomas^[1]
• Vaginal, cervical and/or
• of several organs: of the urinary bladder, papillary renal cell carcinoma, of the prostate, in , and in non-epithelial tumors.

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