OGFOD1

OGFOD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NHX, 4NHY
Identifiers
Aliases	OGFOD1, TPA1, 2-oxoglutarate and iron dependent oxygenase domain containing 1
External IDs	OMIM: 615857 MGI: 2442978 HomoloGene: 41238 GeneCards: OGFOD1
Gene location (Human)
Chr.	Chromosome 16 (human)
End	56,479,104 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	94,794,549 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; muscle of leg; ; biceps brachii; ; left coronary artery; ; vastus lateralis muscle; ; esophagus; ; ovary; ; testicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	2-oxoglutarate-dependent dioxygenase activity; L-ascorbic acid binding; iron ion binding; oxidoreductase activity; dioxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; peptidyl-proline dioxygenase activity; peptidyl-proline 3-dioxygenase activity; metal ion binding;
Cellular component	cytoplasmic stress granule; nucleus; cytoplasm; cytosol;
Biological process	regulation of translational termination; cell population proliferation; peptidyl-proline hydroxylation; protein hydroxylation; stress granule assembly;
	Sources:Amigo / QuickGO
Orthologs
	55239
	270086
	ENSG00000087263
	ENSMUSG00000033009
	Q8N543
	Q3U0K8
NM_018233; NM_001324357; NM_001324358; NM_001324359; NM_001324360;
	NM_001324361; NM_001324362; NM_001324363
	NM_001093757; NM_177767
NP_001311286; NP_001311287; NP_001311288; NP_001311289; NP_001311290;
	NP_001311291; NP_001311292; NP_060703
	NP_001087226; NP_808435
	Wikidata
View/Edit Human	View/Edit Mouse

2-oxoglutarate and iron-dependent oxygenase domain containing 1, also known as OGFOD1, is a human gene.^[5]

Model organisms[]

*Ogfod1* knockout mouse phenotype
Characteristic	Phenotype
Homozygote viability	Normal
Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology	Normal
Peripheral blood lymphocytes	Normal
Micronucleus test	Normal
Heart weight	Normal
Tail epidermis wholemount	Normal
Skin Histopathology	Normal
Brain histopathology	Normal
Salmonella infection	Normal^[6]
Citrobacter infection	Normal^[7]
All tests and analysis from^[8]^[9]

Model organisms have been used in the study of OGFOD1 function. A conditional knockout mouse line, called Ogfod1^{tm1a(KOMP)Wtsi}^[10]^[11] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.^[12]^[13]^[14] Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[8]^[15] Twenty five tests were carried out on homozygous mutant adult mice, however no significant abnormalities were observed.^[8]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000087263 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033009 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: 2-oxoglutarate and iron-dependent oxygenase domain containing 1". Retrieved 2011-08-30.
^ "Salmonella infection data for Ogfod1". Wellcome Trust Sanger Institute.
^ "Citrobacter infection data for Ogfod1". Wellcome Trust Sanger Institute.
^ ^a ^b ^c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
^ "International Knockout Mouse Consortium".
^ "Mouse Genome Informatics".
^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

OGFOD1

Model organisms[]

References[]

Further reading[]