P97

p97 also known as VCP ( Cdc48 in yeast) is a hexameric ATPase of the AAA family which disassembles SNARE proteins after membrane fusion.^[1] It is involved in a fusion of homotypic membranes, protein degradation, and activation of membrane-bound transcription factors.^[2]

References[]

^ Zhang, X; Shaw, A; Bates, PA; Newman, RH; Gowen, B; Orlova, E; Gorman, MA; Kondo, H; Dokurno, P (2000). "Structure of the AAA ATPase p97". Molecular Cell. 6 (6): 1473–84. doi:10.1016/s1097-2765(00)00143-x. PMID 11163219.
^ Madsen, L.; Seeger, M.; Semple, CA.; Hartmann-Petersen, R. (Dec 2009). "New ATPase regulators--p97 goes to the PUB". Int J Biochem Cell Biol. 41 (12): 2380–8. doi:10.1016/j.biocel.2009.05.017. PMID 19497384.

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[1] Zhang, X; Shaw, A; Bates, PA; Newman, RH; Gowen, B; Orlova, E; Gorman, MA; Kondo, H; Dokurno, P (2000). "Structure of the AAA ATPase p97". Molecular Cell. 6 (6): 1473–84. doi:10.1016/s1097-2765(00)00143-x. PMID 11163219.

[2] Madsen, L.; Seeger, M.; Semple, CA.; Hartmann-Petersen, R. (Dec 2009). "New ATPase regulators--p97 goes to the PUB". Int J Biochem Cell Biol. 41 (12): 2380–8. doi:10.1016/j.biocel.2009.05.017. PMID 19497384.

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