PGAM5

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Structures	Swiss-model
Domains	InterPro

PGAM family member 5, mitochondrial serine/threonine protein phosphatase
PGAM family member 5, mitochondrial serine/threonine protein phosphatase
Identifiers
Symbol	PGAM5
NCBI gene	192111
PDB	5MUF
UniProt	Q96HS1
Other data
Locus	Chr. 12 q
Structures
Search for
Structures	Swiss-model
Domains	InterPro

PGAM5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3MXO, 3O0T
Identifiers
Aliases	PGAM5, BXLBV68, PGAM family member 5, mitochondrial serine/threonine protein phosphatase
External IDs	OMIM: 614939 MGI: 1919792 HomoloGene: 14597 GeneCards: PGAM5
Gene location (Human)
Chr.	Chromosome 12 (human)
End	132,722,734 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	110,417,779 bp
RNA expression pattern
	Top expressed in
	cerebellum; ; stomach; ; gastrocnemius muscle; ; muscle of leg; ; pancreas; ; prefrontal cortex; ; esophagus; ; cerebellar hemisphere;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatase activity; phosphoprotein phosphatase activity; hydrolase activity; GO:0005097, GO:0005099, GO:0005100 GTPase activator activity; GO:0001948 protein binding; GO:0032403 protein-containing complex binding; protein serine/threonine phosphatase activity;
Cellular component	integral component of membrane; membrane; mitochondrion; mitochondrial outer membrane;
Biological process	protein dephosphorylation; GO:0060554, GO:0060555 necroptosis; programmed cell death; dephosphorylation; GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; macroautophagy; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	192111
	72542
	ENSG00000247077
	ENSMUSG00000029500
	Q96HS1
	Q8BX10
	NM_138575; NM_001170543; NM_001170544
	NM_001163538; NM_028273
	NP_001164014; NP_001164015; NP_612642
	NP_001157010; NP_082549
	Wikidata
View/Edit Human	View/Edit Mouse

PGAM family member 5 (PGAM5), also known as mitochondrial Serine/threonine-protein phosphatase PGAM5 is related to phosphoglycerate mutase family. It, in humans, is encoded by the PGAM5 gene on chromosome 12.^[5]^[6]

External links[]

PDBe-KB provides an overview of all the structure information available in the PDB for Human Serine/threonine-protein phosphatase PGAM5, mitochondrial

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000247077 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029500 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PGAM5, PGAM family member 5".
^ "UniProtKB: Q96HS1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000247077 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029500 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PGAM5, PGAM family member 5".

[uniprot-6] "UniProtKB: Q96HS1".

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