PIK3R2

PIK3R2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KT1, 2XS6, 3MTT, 3O5Z
Identifiers
Aliases	PIK3R2, MPPH, MPPH1, P85B, p85, p85-BETA, phosphoinositide-3-kinase regulatory subunit 2
External IDs	OMIM: 603157 MGI: 1098772 HomoloGene: 3687 GeneCards: PIK3R2
Gene location (Human)
Chr.	Chromosome 19 (human)
End	18,170,532 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	71,229,357 bp
RNA expression pattern
	Top expressed in
	temporal lobe; ; amygdala; ; prefrontal cortex; ; hippocampus proper; ; dorsolateral prefrontal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol 3-kinase regulator activity; receptor tyrosine kinase binding; 1-phosphatidylinositol-3-kinase regulator activity; GO:0001948 protein binding; protein heterodimerization activity; protein phosphatase binding; GO:0005097, GO:0005099, GO:0005100 GTPase activator activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphotyrosine residue binding; 1-phosphatidylinositol-3-kinase activity;
Cellular component	cytosol; phosphatidylinositol 3-kinase complex; nucleus;
Biological process	Fc-gamma receptor signaling pathway involved in phagocytosis; cellular glucose homeostasis; response to endoplasmic reticulum stress; Fc-epsilon receptor signaling pathway; phosphatidylinositol phosphate biosynthetic process; vascular endothelial growth factor receptor signaling pathway; regulation of autophagy; regulation of phosphatidylinositol 3-kinase activity; cellular response to insulin stimulus; protein transport; phosphatidylinositol 3-kinase signaling; T cell receptor signaling pathway; regulation of small GTPase mediated signal transduction; phosphatidylinositol-mediated signaling; leukocyte migration; positive regulation of transcription by RNA polymerase II; signal transduction; insulin receptor signaling pathway; GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; phosphatidylinositol-3-phosphate biosynthetic process; negative regulation of MAPK cascade; positive regulation of protein kinase B signaling; positive regulation of protein import into nucleus; phosphatidylinositol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	5296
	18709
	ENSG00000105647
	ENSMUSG00000031834
	O00459
	O08908
	NM_005027
	NM_008841
	NP_005018
	NP_032867
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene.^[5]^[6]

Interactions[]

PIK3R2 has been shown to interact with:

CRKL^[7]
Cbl gene,^[8]^[9]
Epidermal growth factor,^[10]
FYN,^[10]
HER2/neu,^[10]
Macrophage colony-stimulating factor,^[10] and
PIK3CD.^[11]

Clinical relevance[]

PIK3R2 mutations were recently shown to be associated with polymicrogyria.^[12]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105647 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031834 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Volinia S, Patracchini P, Otsu M, Hiles I, Gout I, Calzolari E, Bernardi F, Rooke L, Waterfield MD (Apr 1992). "Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta". Oncogene. 7 (4): 789–93. PMID 1314371.
^ "Entrez Gene: PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)".
^ Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (Apr 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)". The Journal of Biological Chemistry. 272 (15): 10248–53. doi:10.1074/jbc.272.15.10248. PMID 9092574.
^ Lin H, Martelli MP, Bierer BE (Jan 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation". International Immunology. 13 (1): 13–22. doi:10.1093/intimm/13.1.13. PMID 11133830.
^ Hartley D, Meisner H, Corvera S (Aug 1995). "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl". The Journal of Biological Chemistry. 270 (31): 18260–3. doi:10.1074/jbc.270.31.18260. PMID 7629144.
^ ^a ^b ^c ^d Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (Dec 1992). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system". The Biochemical Journal. 288 (2): 395–405. doi:10.1042/bj2880395. PMC 1132024. PMID 1334406.
^ Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD (Apr 1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes". Proceedings of the National Academy of Sciences of the United States of America. 94 (9): 4330–5. doi:10.1073/pnas.94.9.4330. PMC 20722. PMID 9113989.
^ Mirzaa, G.; Conti, V.; Timms, A. E.; Smyser, C. D.; Ahmed, S.; Carter, M.; Barnett, S.; Hufnagel, R. B.; Goldstein, A.; Narumi-Kishimoto, Y.; Olds, C.; Collins, S.; Johnston, K.; Deleuze, J. F.; Nitschké, P.; Friend, K.; Harris, C.; Goetsch, A.; Martin, B.; Boyle, E. A.; Parrini, E.; Mei, D.; Tattini, L.; Slavotinek, A.; Blair, E.; Barnett, C.; Shendure, J.; Chelly, J.; Dobyns, W. B.; Guerrini, R. (2015). "Characterisation of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria: a next-generation sequencing study". The Lancet Neurology. 14 (12): 1182–1195. doi:10.1016/S1474-4422(15)00278-1. PMC 4672724. PMID 26520804.

Further reading[]

Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG (Nov 2003). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". Journal of Leukocyte Biology. 74 (5): 676–82. doi:10.1189/jlb.0503206. PMID 12960231. S2CID 11362623.
Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (Dec 1992). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system". The Biochemical Journal. 288 (2): 395–405. doi:10.1042/bj2880395. PMC 1132024. PMID 1334406.
Carpenter CL, Duckworth BC, Auger KR, Cohen B, Schaffhausen BS, Cantley LC (Nov 1990). "Purification and characterization of phosphoinositide 3-kinase from rat liver". The Journal of Biological Chemistry. 265 (32): 19704–11. doi:10.1016/S0021-9258(17)45429-9. PMID 2174051.
Truitt KE, Hicks CM, Imboden JB (Mar 1994). "Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells". The Journal of Experimental Medicine. 179 (3): 1071–6. doi:10.1084/jem.179.3.1071. PMC 2191424. PMID 7509360.
Herbst R, Shearman MS, Jallal B, Schlessinger J, Ullrich A (May 1995). "Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitro". Biochemistry. 34 (17): 5971–9. doi:10.1021/bi00017a026. PMID 7537096.
Craparo A, O'Neill TJ, Gustafson TA (Jun 1995). "Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor". The Journal of Biological Chemistry. 270 (26): 15639–43. doi:10.1074/jbc.270.26.15639. PMID 7541045.
He W, O'Neill TJ, Gustafson TA (Oct 1995). "Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains". The Journal of Biological Chemistry. 270 (40): 23258–62. doi:10.1074/jbc.270.40.23258. PMID 7559478.
Kapeller R, Toker A, Cantley LC, Carpenter CL (Oct 1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin". The Journal of Biological Chemistry. 270 (43): 25985–91. doi:10.1074/jbc.270.43.25985. PMID 7592789.
Hartley D, Meisner H, Corvera S (Aug 1995). "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl". The Journal of Biological Chemistry. 270 (31): 18260–3. doi:10.1074/jbc.270.31.18260. PMID 7629144.
Pandey A, Lazar DF, Saltiel AR, Dixit VM (Dec 1994). "Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity". The Journal of Biological Chemistry. 269 (48): 30154–7. doi:10.1016/S0021-9258(18)43790-8. PMID 7982920.
August A, Dupont B (May 1994). "CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase". International Immunology. 6 (5): 769–74. doi:10.1093/intimm/6.5.769. PMID 8080844.
Fukazawa T, Miyake S, Band V, Band H (Jun 1996). "Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins". The Journal of Biological Chemistry. 271 (24): 14554–9. doi:10.1074/jbc.271.24.14554. PMID 8662998.
Milani D, Mazzoni M, Borgatti P, Zauli G, Cantley L, Capitani S (Sep 1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells". The Journal of Biological Chemistry. 271 (38): 22961–4. doi:10.1074/jbc.271.38.22961. PMID 8798481.
Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (Apr 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)". The Journal of Biological Chemistry. 272 (15): 10248–53. doi:10.1074/jbc.272.15.10248. PMID 9092574.
Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD (Apr 1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes". Proceedings of the National Academy of Sciences of the United States of America. 94 (9): 4330–5. doi:10.1073/pnas.94.9.4330. PMC 20722. PMID 9113989.
Briand G, Barbeau B, Tremblay M (Feb 1997). "Binding of HIV-1 to its receptor induces tyrosine phosphorylation of several CD4-associated proteins, including the phosphatidylinositol 3-kinase". Virology. 228 (2): 171–9. doi:10.1006/viro.1996.8399. PMID 9123823.
Braunger J, Schleithoff L, Schulz AS, Kessler H, Lammers R, Ullrich A, Bartram CR, Janssen JW (Jun 1997). "Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site". Oncogene. 14 (22): 2619–31. doi:10.1038/sj.onc.1201123. PMID 9178760.
Shepherd PR, Navé BT, Rincon J, Nolte LA, Bevan AP, Siddle K, Zierath JR, Wallberg-Henriksson H (Jul 1997). "Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle". The Journal of Biological Chemistry. 272 (30): 19000–7. doi:10.1074/jbc.272.30.19000. PMID 9228082.
Mazerolles F, Barbat C, Fischer A (Sep 1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". European Journal of Immunology. 27 (9): 2457–65. doi:10.1002/eji.1830270946. PMID 9341793. S2CID 33397908.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105647 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031834 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1314371-5] Volinia S, Patracchini P, Otsu M, Hiles I, Gout I, Calzolari E, Bernardi F, Rooke L, Waterfield MD (Apr 1992). "Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta". Oncogene. 7 (4): 789–93. PMID 1314371.

[6] "Entrez Gene: PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)".

[pmid9092574-7] Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (Apr 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)". The Journal of Biological Chemistry. 272 (15): 10248–53. doi:10.1074/jbc.272.15.10248. PMID 9092574.

[pmid11133830-8] Lin H, Martelli MP, Bierer BE (Jan 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation". International Immunology. 13 (1): 13–22. doi:10.1093/intimm/13.1.13. PMID 11133830.

[pmid7629144-9] Hartley D, Meisner H, Corvera S (Aug 1995). "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl". The Journal of Biological Chemistry. 270 (31): 18260–3. doi:10.1074/jbc.270.31.18260. PMID 7629144.

[pmid1334406-10] Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (Dec 1992). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system". The Biochemical Journal. 288 (2): 395–405. doi:10.1042/bj2880395. PMC 1132024. PMID 1334406.

[pmid9113989-11] Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD (Apr 1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes". Proceedings of the National Academy of Sciences of the United States of America. 94 (9): 4330–5. doi:10.1073/pnas.94.9.4330. PMC 20722. PMID 9113989.

[12] Mirzaa, G.; Conti, V.; Timms, A. E.; Smyser, C. D.; Ahmed, S.; Carter, M.; Barnett, S.; Hufnagel, R. B.; Goldstein, A.; Narumi-Kishimoto, Y.; Olds, C.; Collins, S.; Johnston, K.; Deleuze, J. F.; Nitschké, P.; Friend, K.; Harris, C.; Goetsch, A.; Martin, B.; Boyle, E. A.; Parrini, E.; Mei, D.; Tattini, L.; Slavotinek, A.; Blair, E.; Barnett, C.; Shendure, J.; Chelly, J.; Dobyns, W. B.; Guerrini, R. (2015). "Characterisation of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria: a next-generation sequencing study". The Lancet Neurology. 14 (12): 1182–1195. doi:10.1016/S1474-4422(15)00278-1. PMC 4672724. PMID 26520804.

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