Polymerase delta-interacting protein 2 also known as Polymerase delta-interacting protein of 38 kDa (PDIP38) is encoded by the POLDIP2gene in humans.[5][6]
This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. The encoded protein also interacts with proliferating cell nuclear antigen. Some transcripts of this gene overlap in a tail-to-tail orientation with the gene for tumor necrosis factor, alpha-induced protein 1 (TNFAIP1).[6] POLDIP2 / PDIP38 is a moonlighting protein that has been identified in both the nucleus [7] and the mitochondrion [8][9]
Interactions[]
In the nucleus, POLDIP2 has been shown to interact with PCNA,[5] while in the mitochondrion POLDIP2 has been shown to interact with proteins constituting the mitochondrial DNA nucleoid [10] and the AAA+ protease CLPXP [9][11] where it modulates both the specificity and stability of this proteolytic machine.
^Cheng X, Kanki T, Fukuoh A, Ohgaki K, Takeya R, Aoki Y, et al. (December 2005). "PDIP38 associates with proteins constituting the mitochondrial DNA nucleoid". Journal of Biochemistry. 138 (6): 673–8. doi:10.1093/jb/mvi169. PMID16428295.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID16169070. S2CID8235923.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514. S2CID4427026.