PRMT3

PRMT3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FYT, 3SMQ, 4HSG, 4QQN, 4RYL
Identifiers
Aliases	PRMT3, HRMT1L3, protein arginine methyltransferase 3
External IDs	OMIM: 603190 MGI: 1919224 HomoloGene: 24255 GeneCards: PRMT3
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.1 Start 20,387,558 bp[1] End 20,509,338 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B4 Start 49,428,094 bp[2] End 49,508,013 bp[2]
RNA expression pattern Bgee Top expressed in corpus callosum thyroid gland kidney Achilles tendon gastrocnemius muscle heart More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding methyltransferase activity transferase activity GO:0001948 protein binding protein-arginine N-methyltransferase activity nucleic acid binding histone-arginine N-methyltransferase activity protein-arginine omega-N asymmetric methyltransferase activity ribosome binding Cellular component ribosome cytoplasm cytosol nucleus Biological process methylation negative regulation of protein ubiquitination peptidyl-arginine N-methylation protein methylation regulation of transcription, DNA-templated peptidyl-arginine methylation, to asymmetrical-dimethyl arginine histone arginine methylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10196	71974
Ensembl	ENSG00000185238	ENSMUSG00000030505
UniProt	O60678	Q922H1
RefSeq (mRNA)	NM_001145166 NM_001145167 NM_005788	NM_133740
RefSeq (protein)	NP_001138638 NP_001138639 NP_005779	NP_598501
Location (UCSC)	Chr 11: 20.39 – 20.51 Mb	Chr 7: 49.43 – 49.51 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Protein arginine N-methyltransferase 3 is an enzyme that in humans is encoded by the PRMT3 gene.^[5][6]

Model organisms[]

Model organisms have been used in the study of PRMT3 function. A conditional knockout mouse line, called Prmt3^{tm1a(EUCOMM)Wtsi[15][16]} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.^[17][18][19]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[13][20] Twenty seven tests were carried out on mutant mice and seven significant abnormalities were observed.^[13] Fewer than predicted homozygous mutant mice survived until weaning due to hydrocephaly. The remaining tests were carried out on both heterozygous and homozygous mutant adult mice. Male heterzygous mice had a decreased respiratory quotient. Homozygous females had decreased body weight, length and bone mineral density. Homozygous males had abnormal peripheral blood lymphocyte counts and homozygotes of both sex had eye abnormalities.^[13]

Interactions[]

PRMT3 has been shown to interact with RPS2.^[21]

References[]

Further reading[]

External links[]

• PRMT3 human gene location in the UCSC Genome Browser.
• PRMT3 human gene details in the UCSC Genome Browser.

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