PSMA8

PSMA8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4R3O, 4R67
Identifiers
Aliases	PSMA8, PSMA7L, proteasome subunit alpha 8, proteasome 20S subunit alpha 8
External IDs	OMIM: 617841 MGI: 1920927 HomoloGene: 2086 GeneCards: PSMA8
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q11.2 Start 26,133,852 bp[1] End 26,193,355 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A1 Start 14,839,208 bp[2] End 14,895,358 bp[2]
RNA expression pattern Bgee Top expressed in ovary testicle thymus lymph node appendix urinary bladder gastrocnemius muscle More reference expression data BioGPS n/a
Gene ontology Molecular function endopeptidase activity peptidase activity threonine-type endopeptidase activity hydrolase activity Cellular component cytoplasm cytosol spermatoproteasome complex proteasome complex extracellular exosome nucleus proteasome core complex proteasome core complex, alpha-subunit complex Biological process regulation of cellular amino acid metabolic process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent regulation of mRNA stability ubiquitin-dependent protein catabolic process positive regulation of canonical Wnt signaling pathway protein polyubiquitination stimulatory C-type lectin receptor signaling pathway tumor necrosis factor-mediated signaling pathway MAPK cascade proteolysis Fc-epsilon receptor signaling pathway NIK/NF-kappaB signaling anaphase-promoting complex-dependent catabolic process proteolysis involved in cellular protein catabolic process T cell receptor signaling pathway negative regulation of canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of G2/M transition of mitotic cell cycle protein deubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process transmembrane transport regulation of transcription from RNA polymerase II promoter in response to hypoxia post-translational protein modification regulation of hematopoietic stem cell differentiation proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process interleukin-1-mediated signaling pathway regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	143471	73677
Ensembl	ENSG00000154611	ENSMUSG00000036743
UniProt	Q8TAA3	Q9CWH6
RefSeq (mRNA)	NM_001025096 NM_001025097 NM_001308188 NM_144662	NM_001163609 NM_001360823
RefSeq (protein)	NP_001020267 NP_001020268 NP_001295117 NP_653263	NP_001157081 NP_001347752
Location (UCSC)	Chr 18: 26.13 – 26.19 Mb	Chr 18: 14.84 – 14.9 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Proteasome subunit alpha 8 also known as proteasome subunit alpha type-7-like is a protein that in humans is encoded by the PSMA8 gene.^[5] Proteasome subunit alpha 8 is a component of the sperm specific proteasome.^[6]

References[]