Picornavirus internal ribosome entry site (IRES)

Picornavirus internal ribosome entry site (IRES)
Picornavirus internal ribosome entry site (IRES)
	Predicted secondary structure and sequence conservation of IRES_Picorna
Identifiers
Symbol	IRES_Picorna
Rfam	RF00229
Other data
RNA type	Cis-reg; IRES
Domain(s)	Viruses
GO	GO:0043022
SO	SO:0000243
PDB structures	PDBe

This family represents the Picornavirus internal ribosome entry site (IRES) element present in their 5' untranslated region.^[1] These elements were discovered in picornaviruses.^[2] They are cis-acting RNA sequences that adopt diverse three-dimensional structures, recruit the translation machinery and that often operate in association with specific RNA-binding proteins.^[2] IRES elements allow cap and end-independent translation of mRNA in the host cell. It has been found that La autoantigen (La) is required for Coxsackievirus B3 (CVB3) IRES-mediated translation, and it has been suggested that La may be required for the efficient translation of the viral RNA in the pancreas.^[3]^[4] Based on their secondary structure, picornavirus IRES are grouped into four main types. Type I comprises enteroand rhinovirus IRES and type II, those of cardio- and aphthovirus, among others. Type III is used to name hepatitis A IRES.^[2]

References[]

^ Fernández-Miragall, Olga; Quinto, Sonia López de; Martínez-Salas, Encarnación (February 2009). "Relevance of RNA structure for the activity of picornavirus IRES elements". Virus Research. 139 (2): 172–182. doi:10.1016/j.virusres.2008.07.009. PMID 18692097.
^ ^a ^b ^c Martínez-Salas, Encarnación; Francisco-Velilla, Rosario; Fernandez-Chamorro, Javier; Lozano, Gloria; Diaz-Toledano, Rosa (August 2015). "Picornavirus IRES elements: RNA structure and host protein interactions". Virus Research. 206: 62–73. doi:10.1016/j.virusres.2015.01.012. hdl:10261/140186. PMID 25617758.
^ Ray PS, Das S (October 2002). "La autoantigen is required for the internal ribosome entry site-mediated translation of Coxsackievirus B3 RNA". Nucleic Acids Research. 30 (20): 4500–4508. doi:10.1093/nar/gkf583. PMC 137146. PMID 12384597.
^ Liu Z, Carthy CM, Cheung P, Bohunek L, Wilson JE, McManus BM, Yang D (December 1999). "Structural and functional analysis of the 5' untranslated region of coxsackievirus B3 RNA: In vivo translational and infectivity studies of full-length mutants". Virology. 265 (2): 206–217. doi:10.1006/viro.1999.0048. PMID 10600593.

External links[]

http://rfam.xfam.org/family/RF00229 Picornavirus internal ribosome entry site (IRES)
Page for Picornavirus internal ribosome entry site (IRES) at Rfam

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[1] Fernández-Miragall, Olga; Quinto, Sonia López de; Martínez-Salas, Encarnación (February 2009). "Relevance of RNA structure for the activity of picornavirus IRES elements". Virus Research. 139 (2): 172–182. doi:10.1016/j.virusres.2008.07.009. PMID 18692097.

[:0-2] Martínez-Salas, Encarnación; Francisco-Velilla, Rosario; Fernandez-Chamorro, Javier; Lozano, Gloria; Diaz-Toledano, Rosa (August 2015). "Picornavirus IRES elements: RNA structure and host protein interactions". Virus Research. 206: 62–73. doi:10.1016/j.virusres.2015.01.012. hdl:10261/140186. PMID 25617758.

[3] Ray PS, Das S (October 2002). "La autoantigen is required for the internal ribosome entry site-mediated translation of Coxsackievirus B3 RNA". Nucleic Acids Research. 30 (20): 4500–4508. doi:10.1093/nar/gkf583. PMC 137146. PMID 12384597.

[4] Liu Z, Carthy CM, Cheung P, Bohunek L, Wilson JE, McManus BM, Yang D (December 1999). "Structural and functional analysis of the 5' untranslated region of coxsackievirus B3 RNA: In vivo translational and infectivity studies of full-length mutants". Virology. 265 (2): 206–217. doi:10.1006/viro.1999.0048. PMID 10600593.

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