Polyenoic fatty acid isomerase

This article may be confusing or unclear to readers. Please help clarify the article. There might be a discussion about this on the talk page. (October 2018) (Learn how and when to remove this template message)

In enzymology, a polyenoic fatty acid isomerase (EC 5.3.3.13) is an enzyme that catalyzes the chemical reaction

(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate ${\displaystyle \rightleftharpoons }$ (5Z,7E,9E,14Z,17Z)-icosapentaenoate

Hence, this enzyme has one substrate, , and one product, .

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate Delta8,11-Delta7,9-isomerase (trans-double-bond-forming). Other names in common use include PFI, eicosapentaenoate cis-Delta5,8,11,14,17-eicosapentaenoate, cis-Delta5-trans-Delta7,9-cis-Delta14,17 isomerase, (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Delta8,11-Delta7,8-isomerase, (incorrect), (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Delta8,11-Delta7,9-isomerase, and (trans-double-bond-forming).

References[]

• Wise ML, Hamberg M, (1994). "Biosynthesis of conjugated triene-containing fatty acids by a novel isomerase from the red marine alga Ptilota filicina". Biochemistry. 33 (51): 15223–32. doi:10.1021/bi00255a002. PMID 7803384.
• Wise ML, Soderstrom K, Murray TF, (1996). "Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid". Experientia. 52 (1): 88–92. doi:10.1007/BF01922423. PMID 8575565.
• Wise ML, Rossi J, (1997). "Characterization of the substrate binding site of polyenoic fatty acid isomerase, a novel enzyme from the marine alga Ptilota filicina". Biochemistry. 36 (10): 2985–92. doi:10.1021/bi962158v. PMID 9062129.
• Zheng W, Wise ML, Wyrick A, Metz JG, Yuan L, (2002). "Polyenoic fatty acid isomerase from the marine alga Ptilota filicina: protein characterization and functional expression of the cloned cDNA". Arch. Biochem. Biophys. 401 (1): 11–20. doi:10.1016/S0003-9861(02)00002-4. PMID 12054482.