Polyglutamic acid
 | This article is missing information about L vs D-glutamic. (February 2021) |
 Gamma PGA
| |
| Names | |
|---|---|
| Systematic IUPAC name
Poly[imino[1-carboxy-4-oxo-1,4-butanediyl]] | |
| Identifiers | |
| |
| ChemSpider |
|
| Properties | |
| (C5H7NO3)n | |
| Molar mass | variable |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Polyglutamic acid (PGA) is a polymer of the amino acid glutamic acid (GA). Gamma PGA (Poly-γ-glutamic acid, γ-PGA) - the form where the peptide bonds are between the amino group of GA and the carboxyl group at the end of the GA side chain - is a major constituent of the Japanese food nattō. Gamma PGA is formed by bacterial fermentation.
Gamma PGA has a wide number of potential uses ranging from food and medicine to water treatment.[1]
The other isomer, poly-α-glutamic acid is being used as a drug delivery system in cancer treatment[2] and research is underway for its application in a treatment of type I diabetes and its potential use in the production of an AIDS vaccine.[citation needed]
Heavy metal removal[]
G-PGA covalently incorporated into microfiltration membranes via attachment to their membrane pore surfaces exhibited super-high heavy metal sorption ability. Bhattacharyya et al. (1998) G-PGA was found to bind and efficiently remove .99.8% of lead ions from water via a suitable low-pressure ultrafiltration technique. Inbaraj et al. (2006)
References[]
- ^ Bringing Safe Drinking Water to the World
- ^ C. Li; D.F. Yu; A. Newman; F. Cabral; C. Stephens; N.R. Hunter; L. Milas; S. Wallace (1998). "Complete regression of well-established tumors using a novel water-soluble poly(L-glutamic acid)-paclitaxel conjugate". Cancer Research. 58 (11): 2404–2409. PMID 9622081.
- Polyamides