Pseudohypoxia

Pseudohypoxia refers to increased cytosolic ratio of free NAD to NADH in cells, caused by hyperglycemia.^[1] Research has shown that declining levels of NAD+ during aging cause pseudohypoxia, and that raising nuclear NAD+ in old mice reverses pseudohypoxia and metabolic dysfunction, thus reversing the aging process.^[2] It is expected that human NAD trials will begin in 2014.^[3]

Pseudohypoxia is a feature commonly noted in poorly-controlled diabetes.^[1]

References[]

^ ^a ^b [1] Diabetes Magazine: Hyperglycemic Pseudohypoxia and Diabetic Complications, March 12, 1993
^ [2] Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging, Cell, Dec 2013
^ [3] Guardian Newspaper - Online, Dec 2013

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[a-1] [1] Diabetes Magazine: Hyperglycemic Pseudohypoxia and Diabetic Complications, March 12, 1993

[2] [2] Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging, Cell, Dec 2013

[3] [3] Guardian Newspaper - Online, Dec 2013

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Pseudohypoxia

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