Quinism

Neuropsychiatric quinism is a chronic encephalopathy due to intoxication by mefloquine, quinacrine, chloroquine. It is associated with brain dysfunction and brainstem dysfunction. It may be confused as posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI). In the opinion of one medical author it "may have been widely unrecognized in veteran populations, and its symptoms misattributed to other causes."^[1] Symptoms include, but are not limited to, limbic encephalopathy and neurotoxic vestibulopathy.^[2]

Symptoms[]

This neuropsychiatric syndrome is defined by several symptoms that distinguish it from others:^[2]

Very high probability[]

delirium
confusion
disorientation

Moderate probability[]

dementia
amnesia
seizures

Prodromal[]

anxiety
depression
sleep disturbance
abnormal dreams
dizziness
vertigo
paresthesias

References[]

^ Nevin, Remington L. (2019). "Neuropsychiatric Quinism: Chronic Encephalopathy Caused by Poisoning by Mefloquine and Related Quinoline Drugs". Veteran Psychiatry in the US. pp. 315–331. doi:10.1007/978-3-030-05384-0_20. ISBN 978-3-030-05383-3.
^ ^a ^b Nevin, Remington L.; Leoutsakos, Jeannie-Marie (2017). "Identification of a Syndrome Class of Neuropsychiatric Adverse Reactions to Mefloquine from Latent Class Modeling of FDA Adverse Event Reporting System Data". Drugs in R&D. 17 (1): 199–210. doi:10.1007/s40268-016-0167-3. PMC 5318335. PMID 28063022.

[qudef-1] Nevin, Remington L. (2019). "Neuropsychiatric Quinism: Chronic Encephalopathy Caused by Poisoning by Mefloquine and Related Quinoline Drugs". Veteran Psychiatry in the US. pp. 315–331. doi:10.1007/978-3-030-05384-0_20. ISBN 978-3-030-05383-3.

[symptoms-2] Nevin, Remington L.; Leoutsakos, Jeannie-Marie (2017). "Identification of a Syndrome Class of Neuropsychiatric Adverse Reactions to Mefloquine from Latent Class Modeling of FDA Adverse Event Reporting System Data". Drugs in R&D. 17 (1): 199–210. doi:10.1007/s40268-016-0167-3. PMC 5318335. PMID 28063022.

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[2]