RAP2A

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RAP2A

Protein RAP2A PDB 1kao.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1KAO, 2RAP, 3RAP

Identifiers

RAP2A, K-REV, KREV, RAP2, RbBP-30, member of RAS oncogene family

External IDs

OMIM: 179540 MGI: 97855 HomoloGene: 10875 GeneCards: RAP2A

Gene location (Human)

Chr.	Chromosome 13 (human)^[1]

Band	13q32.1	Start	97,434,169 bp^[1]
Band	13q32.1	End	97,469,128 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)^[2]

Band	14 E4\|14 64.72 cM	Start	120,478,444 bp^[2]
Band	14 E4\|14 64.72 cM	End	120,507,194 bp^[2]

RNA expression pattern

Top expressed in
cerebral cortex occipital lobe parietal lobe temporal lobe nucleus accumbens inferior ganglion of vagus nerve medulla oblongata prosencephalon amygdala
More reference expression data


More reference expression data

Gene ontology
Molecular function	nucleotide binding GO:0001948 protein binding magnesium ion binding GO:0006184 GTPase activity GTP binding GDP binding
Cellular component	recycling endosome cytosol endosome membrane plasma membrane recycling endosome membrane midbody
Biological process	actin cytoskeleton reorganization microvillus assembly positive regulation of protein phosphorylation establishment of protein localization Rap protein signal transduction regulation of dendrite morphogenesis cellular protein localization regulation of JNK cascade negative regulation of cell migration establishment of epithelial cell apical/basal polarity positive regulation of protein autophosphorylation protein localization to plasma membrane signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


5911


76108

Ensembl


ENSG00000125249


ENSMUSG00000051615


P10114


Q80ZJ1

RefSeq (mRNA)


NM_021033


NM_029519

RefSeq (protein)


NP_066361


NP_083795

Location (UCSC)

Chr 13: 97.43 – 97.47 Mb

Chr 14: 120.48 – 120.51 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Ras-related protein Rap-2a is a protein that in humans is encoded by the RAP2A gene.^[5] RAP2A is a member of the Ras-related protein family.

Interactions[]

RAP2A has been shown to interact with RUNDC3A,^[6] RASSF5^[7] and RALGDS.^[8]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125249 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051615 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: RAP2A RAP2A, member of RAS oncogene family".
^ Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J (Mar 1998). "Identification of a specific effector of the small GTP-binding protein Rap2". European Journal of Biochemistry. 252 (2): 290–8. doi:10.1046/j.1432-1327.1998.2520290.x. PMID 9523700.
^ Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.
^ Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (Mar 1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". The Journal of Biological Chemistry. 274 (13): 8737–45. doi:10.1074/jbc.274.13.8737. PMID 10085114.

Further reading[]

Lerosey I, Chardin P, de Gunzburg J, Tavitian A (Mar 1991). "The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis". The Journal of Biological Chemistry. 266 (7): 4315–21. PMID 1900290.
Pizon V, Chardin P, Lerosey I, Olofsson B, Tavitian A (Aug 1988). "Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region". Oncogene. 3 (2): 201–4. PMID 3045729.
Farrell FX, Yamamoto K, Lapetina EG (Jan 1993). "Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated". The Biochemical Journal. 289 ( Pt 2) (Pt 2): 349–55. doi:10.1042/bj2890349. PMC 1132174. PMID 8424780.
Cherfils J, Ménétrey J, Le Bras G, Janoueix-Lerosey I, de Gunzburg J, Garel JR, Auzat I (Sep 1997). "Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS". The EMBO Journal. 16 (18): 5582–91. doi:10.1093/emboj/16.18.5582. PMC 1170190. PMID 9312017.
Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J (Mar 1998). "Identification of a specific effector of the small GTP-binding protein Rap2". European Journal of Biochemistry. 252 (2): 290–8. doi:10.1046/j.1432-1327.1998.2520290.x. PMID 9523700.
Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (Mar 1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". The Journal of Biological Chemistry. 274 (13): 8737–45. doi:10.1074/jbc.274.13.8737. PMID 10085114.
Linnemann T, Geyer M, Jaitner BK, Block C, Kalbitzer HR, Wittinghofer A, Herrmann C (May 1999). "Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily". The Journal of Biological Chemistry. 274 (19): 13556–62. doi:10.1074/jbc.274.19.13556. PMID 10224125.
Ménétrey J, Cherfils J (Nov 1999). "Structure of the small G protein Rap2 in a non-catalytic complex with GTP". Proteins. 37 (3): 465–73. doi:10.1002/(SICI)1097-0134(19991115)37:3<465::AID-PROT13>3.0.CO;2-O. PMID 10591105.
de Rooij J, Rehmann H, van Triest M, Cool RH, Wittinghofer A, Bos JL (Jul 2000). "Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs". The Journal of Biological Chemistry. 275 (27): 20829–36. doi:10.1074/jbc.M001113200. PMID 10777494.
Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (Jul 2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nature Neuroscience. 3 (7): 661–9. doi:10.1038/76615. hdl:1842/742. PMID 10862698.
Traver S, Bidot C, Spassky N, Baltauss T, De Tand MF, Thomas JL, Zalc B, Janoueix-Lerosey I, Gunzburg JD (Aug 2000). "RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao". The Biochemical Journal. 350 Pt 1 (Pt 1): 19–29. doi:10.1042/0264-6021:3500019. PMC 1221220. PMID 10926822.
Gao X, Satoh T, Liao Y, Song C, Hu CD, Kariya Ki K, Kataoka T (Nov 2001). "Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras". The Journal of Biological Chemistry. 276 (45): 42219–25. doi:10.1074/jbc.M105760200. PMID 11524421.
Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.
Song C, Satoh T, Edamatsu H, Wu D, Tadano M, Gao X, Kataoka T (Nov 2002). "Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon". Oncogene. 21 (53): 8105–13. doi:10.1038/sj.onc.1206003. PMID 12444546.
Kuiperij HB, de Rooij J, Rehmann H, van Triest M, Wittinghofer A, Bos JL, Zwartkruis FJ (Feb 2003). "Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1593 (2–3): 141–9. doi:10.1016/S0167-4889(02)00365-8. PMID 12581858.
Machida N, Umikawa M, Takei K, Sakima N, Myagmar BE, Taira K, Uezato H, Ogawa Y, Kariya K (Apr 2004). "Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase". The Journal of Biological Chemistry. 279 (16): 15711–4. doi:10.1074/jbc.C300542200. PMID 14966141.
Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". The Journal of Biological Chemistry. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.

v t PDB gallery
1kao: CRYSTAL STRUCTURE OF THE SMALL G PROTEIN RAP2A WITH GDP 2rap: THE SMALL G PROTEIN RAP2A IN COMPLEX WITH GTP 3rap: The small G protein Rap2 in a non catalytic complex with GTP

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