RBM4

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RBM4

Protein RBM4 PDB 2dgt.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2DNQ

Identifiers

RBM4, LARK, RBM4A, ZCCHC21, ZCRB3A, RNA binding motif protein 4

External IDs

OMIM: 602571 MGI: 1100865 HomoloGene: 82510 GeneCards: RBM4

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q13.2	Start	66,638,667 bp^[1]
Band	11q13.2	End	66,668,374 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 A	Start	4,834,321 bp^[2]
Band	19\|19 A	End	4,843,929 bp^[2]

RNA expression pattern

Top expressed in
cerebellar hemisphere prostate lung kidney Body of pancreas ovary
More reference expression data

n/a

Gene ontology
Molecular function	pre-mRNA intronic pyrimidine-rich binding pre-mRNA intronic binding miRNA binding zinc ion binding metal ion binding mRNA 3'-UTR binding GO:0001948 protein binding RNA binding nucleic acid binding mRNA binding cyclin binding
Cellular component	cytoplasm nuclear speck nucleoplasm nucleolus cytoplasmic stress granule nucleus cytosol
Biological process	cell differentiation regulation of nucleocytoplasmic transport RNA processing negative regulation of translation negative regulation of translation in response to stress negative regulation of translational initiation positive regulation of muscle cell differentiation mRNA processing response to arsenic-containing substance regulation of alternative mRNA splicing, via spliceosome cap-independent translational initiation circadian regulation of translation miRNA-mediated gene silencing by inhibition of translation IRES-dependent translational initiation of linear mRNA RNA splicing gene silencing entrainment of circadian clock by photoperiod mRNA cis splicing, via spliceosome
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


5936


19653

Ensembl


ENSG00000173933


ENSMUSG00000094936


Q9BWF3


Q8C7Q4

RefSeq (mRNA)


NM_002896 NM_001198843 NM_001198844


NM_001290122 NM_001290123 NM_001290124 NM_001290125 NM_009032

RefSeq (protein)


NP_001185772 NP_001185773 NP_002887


NP_001277051 NP_001277052 NP_001277053 NP_001277054 NP_033058

Location (UCSC)

Chr 11: 66.64 – 66.67 Mb

Chr 19: 4.83 – 4.84 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

RNA-binding protein 4 is a protein that in humans is encoded by the RBM4 gene.^[5]^[6]^[7]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173933 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000094936 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jackson FR, Banfi S, Guffanti A, Rossi E (Jul 1997). "A novel zinc finger-containing RNA-binding protein conserved from fruitflies to humans". Genomics. 41 (3): 444–52. doi:10.1006/geno.1997.4704. PMID 9169144.
^ Lin JC, Tarn WY (Nov 2005). "Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB". Mol Cell Biol. 25 (22): 10111–21. doi:10.1128/MCB.25.22.10111-10121.2005. PMC 1280272. PMID 16260624.
^ "Entrez Gene: RBM4 RNA binding motif protein 4".

Further reading[]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Bernert G, Fountoulakis M, Lubec G (2003). "Manifold decreased protein levels of matrin 3, reduced motor protein HMP and hlark in fetal Down's syndrome brain". Proteomics. 2 (12): 1752–7. doi:10.1002/1615-9861(200212)2:12<1752::AID-PROT1752>3.0.CO;2-Y. PMID 12469345.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Petersen HH, Hilpert J, Militz D, et al. (2003). "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule". J. Cell Sci. 116 (Pt 3): 453–61. doi:10.1242/jcs.00243. PMID 12508107.
Lai MC, Kuo HW, Chang WC, Tarn WY (2003). "A novel splicing regulator shares a nuclear import pathway with SR proteins". EMBO J. 22 (6): 1359–69. doi:10.1093/emboj/cdg126. PMC 151058. PMID 12628928.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Diederichs S, Bäumer N, Ji P, et al. (2004). "Identification of interaction partners and substrates of the cyclin A1-CDK2 complex". J. Biol. Chem. 279 (32): 33727–41. doi:10.1074/jbc.M401708200. PMID 15159402.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Kar A, Havlioglu N, Tarn WY, Wu JY (2006). "RBM4 interacts with an intronic element and stimulates tau exon 10 inclusion". J. Biol. Chem. 281 (34): 24479–88. doi:10.1074/jbc.M603971200. PMC 2072872. PMID 16777844.
Markus MA, Heinrich B, Raitskin O, et al. (2006). "WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo". Exp. Cell Res. 312 (17): 3379–88. doi:10.1016/j.yexcr.2006.07.008. PMID 16934801.
Lin JC, Hsu M, Tarn WY (2007). "Cell stress modulates the function of splicing regulatory protein RBM4 in translation control". Proc. Natl. Acad. Sci. U.S.A. 104 (7): 2235–40. doi:10.1073/pnas.0611015104. PMC 1893002. PMID 17284590.

v t PDB gallery
2dgt: Solution structure of the second RNA binding domain in RNA-binding protein 30 2dnq: Solution structure of RNA binding domain 1 in RNA-binding protein 30

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