RBM47

RBM47
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DIS
Identifiers
Aliases	RBM47, NET18, RNA binding motif protein 47
External IDs	MGI: 2384294 HomoloGene: 36932 GeneCards: RBM47
Gene location (Human)
Chr.	Chromosome 4 (human)
End	40,630,875 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	66,330,461 bp
RNA expression pattern
	Top expressed in
	kidney; ; renal cortex; ; colon; ; renal medulla; ; parotid gland; ; salivary gland; ; duodenum;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleic acid binding; RNA binding; mRNA binding;
Cellular component	nucleus;
Biological process	hematopoietic progenitor cell differentiation; cytidine to uridine editing;
	Sources:Amigo / QuickGO
Orthologs
	54502
	245945
	ENSG00000163694
	ENSMUSG00000070780
	A0AV96
	Q91WT8
	NM_001098634; NM_019027; NM_001371113; NM_001371114
	NM_001127382; NM_001291226; NM_139065; NM_178446
	NP_001092104; NP_061900; NP_001358042; NP_001358043
	NP_001120854; NP_001278155; NP_620704; NP_848541
	Wikidata
View/Edit Human	View/Edit Mouse

RNA binding motif protein 47 is a protein in humans that is encoded by the RBM47 gene in chromosome 4. ^[5]

Model organisms[]

Model organisms have been used in the study of RBM47 function. A conditional knockout mouse line called Rbm47^{tm1a(EUCOMM)Wtsi} was generated at the Wellcome Trust Sanger Institute.^[6] Male and female animals underwent a standardized phenotypic screen^[7] to determine the effects of deletion.^[8]^[9]^[10]^[11] Additional screens performed: - In-depth immunological phenotyping^[12]

*Rbm47* knockout mouse phenotype
Characteristic	Phenotype
All data available at.^[7]^[12]
Insulin	Normal
Homozygous viability at P14	Normal
Homozygous Fertility	Normal
Body weight	Normal
Neurological assessment	Normal
Grip strength	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology 16 Weeks	Normal
Peripheral blood leukocytes 16 Weeks	Normal
Heart weight	Normal
Salmonella infection	Normal
Spleen Immunophenotyping	Normal
Mesenteric Lymph Node Immunophenotyping	Normal
Epidermal Immune Composition	Normal
Influenza Challenge	Normal

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163694 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070780 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: RNA binding motif protein 47". Retrieved 2013-06-01.
^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
^ ^a ^b "International Mouse Phenotyping Consortium".
^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
^ ^a ^b "Infection and Immunity Immunophenotyping (3i) Consortium".

RBM47

Model organisms[]

References[]

Further reading[]