RDH11 Identifiers Aliases RDH11 , ARSDR1, CGI82, HCBP12, MDT1, PSDR1, RALR1, SCALD, SDR7C1, RDJCSS, retinol dehydrogenase 11 (all-trans/9-cis/11-cis), retinol dehydrogenase 11External IDs OMIM : 607849 MGI : 102581 HomoloGene : 100724 GeneCards : RDH11 Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 14: 67.68 – 67.7 Mb n/a PubMed search[2] [3] Wikidata
Retinol dehydrogenase 11 is an enzyme that in humans is encoded by the RDH11 gene .[4] [5] [6] [7]
RHD11, a member of the short-chain dehydrogenase/reductase (SDR) superfamily of oxidoreductases , is expressed at high levels in prostate epithelium, and its expression is regulated by androgens .[supplied by OMIM][7]
Clinical significance [ ]
Mutations in RDH11 are associated to retinitis pigmentosa .[8]
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000072042 - Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Haeseleer F, Jang GF, Imanishi Y, Driessen CA, Matsumura M, Nelson PS, Palczewski K (Nov 2002). "Dual-substrate Specificity Short Chain Retinol Dehydrogenases from the Vertebrate Retina" . J Biol Chem . 277 (47): 45537–46. doi :10.1074/jbc.M208882200 . PMC 1435693 . PMID 12226107 .
^ Hara T, Harada N, Mitsui H, Miura T, Ishizaka T, Miyajima A (Aug 1994). "Characterization of cell phenotype by a novel cDNA library subtraction system: expression of CD8 alpha in a mast cell-derived interleukin-4-dependent cell line" . Blood . 84 (1): 189–99. doi :10.1182/blood.V84.1.189.189 . PMID 8018917 .
^
^ a b "Entrez Gene: RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)" .
^ Xie, Y. A.; Lee, W; Cai, C; Gambin, T; Nõupuu, K; Sujirakul, T; Ayuso, C; Jhangiani, S; Muzny, D; Boerwinkle, E; Gibbs, R; Greenstein, V. C.; Lupski, J. R.; Tsang, S. H.; Allikmets, R (2014). "New syndrome with retinitis pigmentosa is caused by nonsense mutations in retinol dehydrogenase RDH11" . Human Molecular Genetics . 23 (21): 5774–5780. doi :10.1093/hmg/ddu291 . PMC 4189905 . PMID 24916380 .
Further reading [ ]
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics" . Genome Res . 10 (5): 703–13. doi :10.1101/gr.10.5.703 . PMC 310876 . PMID 10810093 .
Lin B, White JT, Ferguson C, et al. (2001). "Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium". Cancer Res . 61 (4): 1611–8. PMID 11245473 .
Kedishvili NY, Chumakova OV, Chetyrkin SV, et al. (2002). "Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1)" . J. Biol. Chem . 277 (32): 28909–15. doi :10.1074/jbc.M202588200 . PMID 12036956 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Li K, Wang L, Cheng J, et al. (2003). "Interaction between hepatitis C virus core protein and translin protein--a possible molecular mechanism for hepatocellular carcinoma and lymphoma caused by hepatitis C virus" . World J. Gastroenterol . 9 (2): 300–3. doi :10.3748/wjg.v9.i2.300 . PMC 4611333 . PMID 12532453 .
Belyaeva OV, Stetsenko AV, Nelson P, Kedishvili NY (2004). "Properties of short-chain dehydrogenase/reductase RalR1: characterization of purified enzyme, its orientation in the microsomal membrane, and distribution in human tissues and cell lines". Biochemistry . 42 (50): 14838–45. doi :10.1021/bi035288u . PMID 14674758 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries" . DNA Res . 12 (2): 117–26. doi :10.1093/dnares/12.2.117 . PMID 16303743 .
Kasus-Jacobi A, Birch DG, Anderson RE (2007). "Photoreceptor retinol dehydrogenases. An attempt to characterize the function of Rdh11" . Adv. Exp. Med. Biol . Advances in Experimental Medicine and Biology. 572 : 505–11 . doi :10.1007/0-387-32442-9_70 . ISBN 978-0-387-28464-4 . PMID 17249616 .
Roni V, Carpio R, Wissinger B (2007). "Mapping of transcription start sites of human retina expressed genes" . BMC Genomics . 8 : 42. doi :10.1186/1471-2164-8-42 . PMC 1802077 . PMID 17286855 .