RGS11

RGS11
Identifiers
Aliases	RGS11, RS11, regulator of G-protein signaling 11, regulator of G protein signaling 11
External IDs	OMIM: 603895 MGI: 1354739 HomoloGene: 77719 GeneCards: RGS11
Gene location (Human)
Chr.	Chromosome 16 (human)
End	275,980 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	26,430,298 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; pituitary gland; ; anterior pituitary; ; hypothalamus; ; dorsolateral prefrontal cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G-protein beta-subunit binding; GO:0005097, GO:0005099, GO:0005100 GTPase activator activity; GO:0006184 GTPase activity;
Cellular component	cytoplasm; plasma membrane; protein-containing complex; intracellular anatomical structure;
Biological process	G protein-coupled receptor signaling pathway; negative regulation of signal transduction; GO:0007243 intracellular signal transduction; regulation of G protein-coupled receptor signaling pathway; GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	8786
	50782
	ENSG00000076344
	ENSMUSG00000024186
	O94810
	Q9Z2H1
	NM_001286485; NM_001286486; NM_003834; NM_183337
	NM_001081069
	NP_001273414; NP_001273415; NP_003825; NP_899180
	NP_001074538
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of G-protein signaling 11 is a protein that in humans is encoded by the RGS11 gene.^[5]^[6]

The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000076344 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024186 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP (Nov 1998). "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits". Proc Natl Acad Sci U S A. 95 (22): 13307–12. Bibcode:1998PNAS...9513307S. doi:10.1073/pnas.95.22.13307. PMC 23793. PMID 9789084.
^ ^a ^b "Entrez Gene: RGS11 regulator of G-protein signalling 11".

Further reading[]

Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16" (PDF). Nature. 432 (7020): 988–94. doi:10.1038/nature03187. PMID 15616553. S2CID 4362044.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488.
Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
Snow BE, Betts L, Mangion J, et al. (1999). "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489–94. Bibcode:1999PNAS...96.6489S. doi:10.1073/pnas.96.11.6489. PMC 26909. PMID 10339615.
Gold SJ, Ni YG, Dohlman HG, Nestler EJ (1997). "Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain". J. Neurosci. 17 (20): 8024–37. doi:10.1523/JNEUROSCI.17-20-08024.1997. PMC 6793903. PMID 9315921.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000076344 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024186 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9789084-5] Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP (Nov 1998). "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits". Proc Natl Acad Sci U S A. 95 (22): 13307–12. Bibcode:1998PNAS...9513307S. doi:10.1073/pnas.95.22.13307. PMC 23793. PMID 9789084.

[entrez-6] "Entrez Gene: RGS11 regulator of G-protein signalling 11".

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