RGS13

RGS13
Identifiers
Aliases	RGS13, regulator of G protein signaling 13
External IDs	OMIM: 607190 MGI: 2180585 HomoloGene: 14774 GeneCards: RGS13
Gene location (Human)
Chr.	Chromosome 1 (human)
End	192,660,311 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	144,053,110 bp
RNA expression pattern
	Top expressed in
	thymus; ; appendix; ; lymph node; ; small intestine; ; duodenum; ; jejunal mucosa; ; pancreas; ; lung;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GO:0005097, GO:0005099, GO:0005100 GTPase activator activity; GO:0006184 GTPase activity;
Cellular component	cytoplasm; cytosol; nucleus; plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; negative regulation of signal transduction; negative regulation of G protein-coupled receptor signaling pathway; GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	6003
	246709
	ENSG00000127074
	ENSMUSG00000051079
	O14921
	Q8K443
	NM_144766; NM_002927
	NM_153171
	NP_002918; NP_658912
	NP_694811
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of G-protein signaling 13 (RGS13) is a protein that in humans is encoded by the RGS13 gene.^[5]^[6]

RGS13 is a member of R4 subfamily of the Regulator of G protein signaling (RGS) protein family, whose members have only short peptide sequences flanking the RGS domain. RGS13 suppresses the immunoglobulin E- mediated allergic responses.^[7]

RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127074 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051079 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Johnson EN, Druey KM (May 2002). "Functional characterization of the G protein regulator RGS13". J Biol Chem. 277 (19): 16768–16774. doi:10.1074/jbc.M200751200. PMID 11875076.
^ ^a ^b "Entrez Gene: RGS13 regulator of G-protein signalling 13".
^ Bansal G, Xie Z, Rao S, Nocka KH, Druey KM (2008). "Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13". Nat. Immunol. 9 (1): 73–80. doi:10.1038/ni1533. PMC 2387203. PMID 18026105.

Further reading[]

Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–321. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Han JI, Huang NN, Kim DU, Kehrl JH (2006). "RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization". J. Leukoc. Biol. 79 (6): 1357–1368. doi:10.1189/jlb.1105693. PMID 16565322. S2CID 39672919.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Islam TC, Asplund AC, Lindvall JM, et al. (2003). "High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma". Leukemia. 17 (9): 1880–1890. doi:10.1038/sj.leu.2403057. PMID 12970790.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–185. doi:10.1006/geno.2002.6693. PMID 11829488.
Druey KM, Blumer KJ, Kang VH, Kehrl JH (1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family". Nature. 379 (6567): 742–746. Bibcode:1996Natur.379..742D. doi:10.1038/379742a0. PMID 8602223. S2CID 4362632.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127074 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051079 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11875076-5] Johnson EN, Druey KM (May 2002). "Functional characterization of the G protein regulator RGS13". J Biol Chem. 277 (19): 16768–16774. doi:10.1074/jbc.M200751200. PMID 11875076.

[entrez-6] "Entrez Gene: RGS13 regulator of G-protein signalling 13".

[pmid18026105-7] Bansal G, Xie Z, Rao S, Nocka KH, Druey KM (2008). "Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13". Nat. Immunol. 9 (1): 73–80. doi:10.1038/ni1533. PMC 2387203. PMID 18026105.

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