RNF139

RNF139
Identifiers
Aliases	RNF139, HRCA1, RCA1, TRC8, ring finger protein 139
External IDs	OMIM: 603046 MGI: 1923091 HomoloGene: 5222 GeneCards: RNF139
Gene location (Human)
Chr.	Chromosome 8 (human)
End	124,488,618 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	58,778,906 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; testicle; ; visceral pleura; ; parietal pleura; ; ovary;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity; zinc ion binding; metal ion binding; ubiquitin-protein transferase activity; ubiquitin-like protein transferase activity; protease binding; GO:0001948 protein binding; transferase activity; ligase activity; signaling receptor activity;
Cellular component	integral component of membrane; membrane; endoplasmic reticulum; Derlin-1 retrotranslocation complex; endoplasmic reticulum membrane; endoplasmic reticulum quality control compartment; endomembrane system;
Biological process	negative regulation of translation; ERAD pathway; regulation of ER to Golgi vesicle-mediated transport; regulation of protein ubiquitination; protein polyubiquitination; regulation of protein processing; positive regulation of ubiquitin-dependent protein catabolic process; protein destabilization; protein ubiquitination; negative regulation of cell population proliferation; proteasome-mediated ubiquitin-dependent protein catabolic process; endoplasmic reticulum mannose trimming; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	11236
	75841
	ENSG00000170881
	ENSMUSG00000037075
	Q8WU17
	Q7TMV1
	NM_007218
	NM_175226
	NP_009149
	NP_780435
	Wikidata
View/Edit Human	View/Edit Mouse

RING finger protein 139, also known as TRC8, is a protein that in humans is encoded by the RNF139 gene.^[5]^[6]

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medullary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP].^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170881 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037075 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gemmill RM, West JD, Boldog F, Tanaka N, Robinson LJ, Smith DI, Li F, Drabkin HA (Sep 1998). "The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8". Proc Natl Acad Sci U S A. 95 (16): 9572–7. Bibcode:1998PNAS...95.9572G. doi:10.1073/pnas.95.16.9572. PMC 21380. PMID 9689122.
^ ^a ^b "Entrez Gene: RNF139 ring finger protein 139".

Further reading[]

Poland KS, Azim M, Folsom M, et al. (2007). "A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma". Genes Chromosomes Cancer. 46 (9): 805–12. doi:10.1002/gcc.20466. PMID 17539022. S2CID 44344160.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Brauweiler A, Lorick KL, Lee JP, et al. (2007). "RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene". Oncogene. 26 (16): 2263–71. doi:10.1038/sj.onc.1210017. PMID 17016439.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gemmill RM, Bemis LT, Lee JP, et al. (2002). "The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway". Oncogene. 21 (22): 3507–16. doi:10.1038/sj.onc.1205437. PMID 12032852.
Lorick KL, Jensen JP, Fang S, et al. (1999). "RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11364–9. Bibcode:1999PNAS...9611364L. doi:10.1073/pnas.96.20.11364. PMC 18039. PMID 10500182.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170881 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037075 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9689122-5] Gemmill RM, West JD, Boldog F, Tanaka N, Robinson LJ, Smith DI, Li F, Drabkin HA (Sep 1998). "The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8". Proc Natl Acad Sci U S A. 95 (16): 9572–7. Bibcode:1998PNAS...95.9572G. doi:10.1073/pnas.95.16.9572. PMC 21380. PMID 9689122.

[entrez-6] "Entrez Gene: RNF139 ring finger protein 139".

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