ROCK2
Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene. [5]Fasudil is an inhibitor of ROCK protein.
Function[]
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.
References[]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000134318 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020580 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Rho associated coiled-coil containing protein kinase 2". Retrieved 2016-04-21.
Further reading[]
- Trauger JW, Lin FF, Turner MS, Stephens J, LoGrasso PV (2002). "Kinetic mechanism for human Rho-Kinase II (ROCK-II)". Biochemistry. 41 (28): 8948–53. doi:10.1021/bi0258243. PMID 12102637.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
External links[]
Categories:
- Genes on human chromosome 2
- Human chromosome 2 gene stubs