From Wikipedia, the free encyclopedia
RTI-32
Methyl (1R ,2S ,3S ,5S )-8-methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate
CAS Number PubChem CID ChemSpider ChEMBL CompTox Dashboard (EPA ) Formula C 17 H 23 N O 2 Molar mass 273.376 g·mol−1 3D model (JSmol )
CC1=CC=C(C=C1)[C@H]2C[C@@H]3CC[C@H]([C@H]2C(=O)OC)N3C
InChI=1S/C17H23NO2/c1-11-4-6-12(7-5-11)14-10-13-8-9-15(18(13)2)16(14)17(19)20-3/h4-7,13-16H,8-10H2,1-3H3/t13-,14+,15+,16-/m0/s1
Key:MMKZDDDDODERSJ-JJXSEGSLSA-N
(–)-2β-Carbomethoxy-3β-(4-tolyl )tropane (RTI-4229 -32 , tolpane ) is a phenyltropane -based cocaine analogue that has similar properties in vitro to related drugs such as RTI-31 .[1] [2]
Comparison of Data
Compound
DAT
DA
NET
NA
SERT
5HT
ED50
Troparil
23
49.8
550
37.2
178
173
0.34
RTI-32
1.7
7.02
36
8.42
23
19.4
0.31
RTI-31
1.1
3.68
22
5.86
4.0
5.0
0.13
3'4'-xylyl
0.43
unknown
44
unknown
2.42
unknown
See also [ ]
References [ ]
^ Remy P, Doder M, Lees A, Turjanski N, Brooks D (June 2005). "Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system" . Brain . 128 (Pt 6): 1314–22. doi :10.1093/brain/awh445 . PMID 15716302 .
^ Xu L, Izenwasser S, Katz JL, Kopajtic T, Klein-Stevens C, Zhu N, et al. (March 2002). "Synthesis and biological evaluation of 2-substituted 3beta-tolyltropane derivatives at dopamine, serotonin, and norepinephrine transporters". Journal of Medicinal Chemistry . 45 (6): 1203–10. doi :10.1021/jm010453u . PMID 11881989 .
Phenyltropanes (classifications )
2-Carboxymethyl Esters
Troparil
WIN 35428
RTI-31
RTI-32
RTI-51
RTI-55
RTI-83
(3,4-Disubstituted Phenyl)-tropanes
Dichloropane
RTI-112
RTI-353
Arylcarboxy Carboxyalkyl Acyl β,α Stereochemistry α,β Stereochemistry
Brasofensine
Tesofensine
NS2359
Heterocycles: 3-Substituted-isoxazol-5-yl Heterocycles: 3-Substituted-1,2,4-oxadiazole N-alkyl N-replaced (S,O,C) Irreversible Nortropanes (N-demethylated)
Stimulants
Adamantanes
Adapromine
Amantadine
Bromantane
Memantine
Rimantadine
Adenosine antagonists Alkylamines
Cyclopentamine
Cypenamine
Cyprodenate
Heptaminol
Isometheptene
Levopropylhexedrine
Methylhexaneamine
Octodrine
Propylhexedrine
Tuaminoheptane
Ampakines Arylcyclohexylamines Benzazepines
6-Br-APB
SKF-77434
SKF-81297
SKF-82958
Cathinones Cholinergics Convulsants Eugeroics Oxazolines Phenethylamines Phenylmorpholines Piperazines
2C-B-BZP
3C-PEP
BZP
CM156
DBL-583
GBR-12783
GBR-12935
GBR-13069
GBR-13098
GBR-13119
MeOPP
MBZP
oMPP
Vanoxerine
Piperidines
1-Benzyl-4-(2-(diphenylmethoxy)ethyl)piperidine
2-Benzylpiperidine
2-Methyl-3-phenylpiperidine
3,4-Dichloromethylphenidate
4-Benzylpiperidine
4-Fluoromethylphenidate
4-Methylmethylphenidate
Desoxypipradrol
Difemetorex
Diphenylpyraline
Ethylnaphthidate
Ethylphenidate
Methylnaphthidate
Isopropylphenidate
JZ-IV-10
Methylphenidate (Dexmethylphenidate )
Nocaine
Phacetoperane
Pipradrol
Propylphenidate
SCH-5472
Pyrrolidines Racetams
Oxiracetam
Phenylpiracetam
Phenylpiracetam hydrazide
Tropanes Tryptamines Others ATC code : N06B
D1 -like
Agonists
Ergolines : Cabergoline
CY-208,243
Dihydroergocryptine
Lisuride
Pergolide
Terguride
Phenethylamines :
Deoxyepinephrine (N-methyldopamine, epinine)
Dopexamine
Etilevodopa
Ibopamine
L -DOPA (levodopa)
Melevodopa
L -Phenylalanine
L -Tyrosine
Others : A-68930
Apomorphine
Nuciferine
PF-6649751
Propylnorapomorphine
Rotigotine
SKF-89,145
Stepholidine
Tavapadon
Tetrahydropalmatine
PAMs Antagonists
Typical antipsychotics : Butaclamol
Chlorpromazine
Chlorprothixene
Flupentixol (flupenthixol) (+melitracen )
Fluphenazine
Loxapine
Perphenazine (+amitriptyline )
Thioridazine
Thiothixene
Trifluoperazine (+tranylcypromine )
Zuclopenthixol
Atypical antipsychotics : Asenapine
Clorotepine
Clotiapine
Clozapine
DHA-clozapine
Fluperlapine
Iloperidone
Norclozapine
Olanzapine (+fluoxetine )
Paliperidone
Quetiapine
Risperidone
Zicronapine
Ziprasidone
Zotepine
Others :
Ecopipam
EEDQ
Metitepine (methiothepin)
Perlapine
SCH-23390
D2 -like
Agonists
Adamantanes : Amantadine
Memantine
Rimantadine
Aminotetralins : 5-OH-DPAT
7-OH-DPAT
8-OH-PBZI
Rotigotine
UH-232
Ergolines : Bromocriptine
Cabergoline
Chanoclavine
Dihydroergocryptine
Epicriptine
Ergocornine
Lergotrile
Lisuride
LSD
Pergolide
Terguride
Phenethylamines : Deoxyepinephrine (N-methyldopamine, epinine)
Dopexamine
Etilevodopa
Ibopamine
L -DOPA (levodopa)
L -Phenylalanine
L -Tyrosine
Melevodopa
Atypical antipsychotics : Alentemol (U-66444B)
Aripiprazole (+sertraline )
Aripiprazole lauroxil
Bifeprunox
Brexpiprazole
Brilaroxazine
Cariprazine
F-15063
Lumateperone
Norclozapine
Others : 3-PPP
A-412997
ABT-670
ABT-724
Adrafinil
Aplindore
Apomorphine
Arketamine
Armodafinil
BP-897
Captodiame
CP-226,269
Dizocilpine
Esketamine
Flibanserin
Ketamine
Mesulergine
Modafinil
OSU-6162
Pardoprunox
PD-128,907
PD-168,077
PF-219,061
PF-592,379
Phencyclidine
Piribedil
Pramipexole
Preclamol
Propylnorapomorphine
Pukateine
Quinagolide
Quinelorane
Quinpirole
RDS-127
Ro10-5824
Ropinirole
Roxindole
Salvinorin A
SKF-83,959
Sumanirole
Talipexole
Umespirone
WAY-100,635
Antagonists
Antiemetics/gastroprokinetics/sedatives : Aceprometazine
AS-8112
Alimemazine
Alizapride
Benzquinamide
Bromopride
Clebopride
Deudomperidone
Domperidone
Eticlopride
Hydroxyzine
Itopride
Metoclopramide
Metopimazine
Promethazine
Thiethylperazine
Trimethobenzamide
Antidepressants : Amoxapine
Nefazodone
Opipramol
Propiomazine
Trimipramine
Others : 3-PPP
Azapride
Bromerguride
Bromocriptine
Buspirone
Desmethoxyfallypride
EEDQ
F-15063
Fallypride
Fananserin
Fenfluramine
Iodobenzamide
L-741,626
L-745,870
Levofenfluramine
Metergoline
Metitepine (methiothepin)
N-Methylspiperone
Nafadotride
Nuciferine
PNU-99,194
Pridopidine
Raclopride
Sarizotan
SB-277,011-A
Sonepiprazole
Spiroxatrine
Stepholidine
Terguride
Tetrahydropalmatine
Tiapride
UH-232
Yohimbine
See also: Receptor/signaling modulators
Adrenergics
Serotonergics
Monoamine reuptake inhibitors
Monoamine releasing agents
Monoamine metabolism modulators
Monoamine neurotoxins
Categories :
Tropanes RTI compounds Dopamine reuptake inhibitors Sympathomimetic amines Medical imaging Neuroimaging Hidden categories:
Chemical pages without DrugBank identifier Articles without KEGG source Articles without UNII source Drugs missing an ATC code Drugs with no legal status