rs6311

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SNP: rs6311
Name(s)-1438G/A, -1438A/G, A-1438G, G-1438A
GeneHTR2A
Chromosome13
External databases
EnsemblHuman SNPView
dbSNP6311
HapMap6311
SNPedia6311
SzGeneMeta-analysis
Overview

In genetics, rs6311 is a gene variation—a single nucleotide polymorphism (SNP)—in the human HTR2A gene that codes for the 5-HT2A receptor. 5-HT2A is a neuroreceptor, and several scientific studies have investigated the effect of the genetic variation on personality, e.g., personality traits measured with the Temperament and Character Inventory[1][2][3][4] or with a psychological task measuring impulsive behavior.[5] The SNP has also been investigated in rheumatology studies.[6][7]

Some research studies may refer to this gene variation as a C/T SNP,[2] while others refer to it as a G/A polymorphism in the promoter region, thus writing it as, e.g., −1438 G/A or 1438G>A.[8][9][10]

As of 2008, meta-analysis of research studies indicates that people with the A-allele may have slightly elevated risk of schizophrenia.[11]

rs6313, rs6314, and rs7997012 are other investigated SNPs in the HTR2A gene.

References[]

  1. ^ Ham BJ, Kim YH, Choi MJ, Cha JH, Choi YK, Lee MS (January 2004). "Serotonergic genes and personality traits in the Korean population". Neurosci. Lett. 354 (1): 2–5. doi:10.1016/S0304-3940(03)00753-5. PMID 14698468. S2CID 22448256.
  2. ^ Jump up to: a b Giegling I, Hartmann AM, Möller HJ, Rujescu D (November 2006). "Anger- and aggression-related traits are associated with polymorphisms in the 5-HT-2A gene". Journal of Affective Disorders. 96 (1–2): 75–81. doi:10.1016/j.jad.2006.05.016. PMID 16814396.
  3. ^ Unschuld PG, Ising M, Erhardt A, Lucae S, Kloiber S, Kohli M, Salyakina D, Welt T, Kern N, Lieb R, Uhr M, Binder EB, Müller-Myhsok B, Holsboer F, Keck ME (June 2007). "Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder". Am J Med Genet B. 144B (4): 424–429. doi:10.1002/ajmg.b.30412. PMID 17440930. S2CID 10374372.
  4. ^ Serretti A, Calati R, Giegling I, Hartmann AM, Möller HJ, Colombo C, Rujescu D (August 2007). "5-HT2A SNPs and the Temperament and Character Inventory". Progress in Neuro-Psychopharmacology and Biological Psychiatry. 31 (6): 1275–1281. doi:10.1016/j.pnpbp.2007.05.008. PMID 17590256. S2CID 2646380.
  5. ^ Nomura M, Kusumi I, Kaneko M, Masui T, Daiguji M, Ueno T, Koyama T, Nomura Y (July 2006). "Involvement of a polymorphism in the 5-HT2A receptor gene in impulsive behavior". Psychopharmacology. 187 (1): 30–35. doi:10.1007/s00213-006-0398-z. PMID 16767413. S2CID 12155339.
  6. ^ Tander B, Gunes S, Boke O, Alayli G, Kara N, Bagci H, Canturk F (May 2008). "Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility". . 28 (7): 685–691. doi:10.1007/s00296-008-0525-8. PMID 18196244. S2CID 29817254.
  7. ^ Kling A, Seddighzadeh M, Ärlestig L, Alfredsson L, Rantapää-Dahlqvist S, Padyukov L (2007). "Genetic variations in the serotonin 5-HT2A receptor gene (HTR2A) are associated with rheumatoid arthritis". Ann. Rheum. Dis. 67 (8): 1111–5. doi:10.1136/ard.2007.074948. PMID 18006541. S2CID 3081132.
  8. ^ Reynolds CA, Jansson M, Gatz M, Pedersen NL (January 2006). "Longitudinal change in memory performance associated with HTR2A polymorphism". Neurobiology of Aging. 27 (1): 150–154. doi:10.1016/j.neurobiolaging.2004.12.009. PMID 16298250. S2CID 32745716.
  9. ^ Halder I, Muldoon MF, Ferrell RE, Manuck SB (December 2007). "Serotonin Receptor 2A (HTR2A) Gene Polymorphisms Are Associated with Blood Pressure, Central Adiposity, and the Metabolic Syndrome". . 5 (4): 323–330. doi:10.1089/met.2007.0008. PMC 3237193. PMID 18370802.
  10. ^ Saiz PA, Garcia-Portilla MP, Arango C, Morales B, Bascaran MT, Martinez-Barrondo S, Florez G, Sotomayor E, Paredes B, Alvarez C, San Narciso G, Carreño E, Bombin I, Alvarez V, Coto E, Fernandez JM, Bousoño M, Bobes J (April 2008). "Association study between obsessive–compulsive disorder and serotonergic candidate genes". Progress in Neuro-Psychopharmacology and Biological Psychiatry. 32 (3): 765–770. doi:10.1016/j.pnpbp.2007.12.005. PMID 18191318. S2CID 35024576.
  11. ^ "Meta-Analysis of All Published Schizophrenia-Association Studies (Case-Control Only) rs6311". Schizophrenia Research Forum. Retrieved 2008-06-10.


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