rs7341475
| SNP: rs7341475 | |
|---|---|
| Gene | RELN |
| Chromosome | 7 |
| Region | Intron 4 |
| External databases | |
| Ensembl | Human SNPView |
| dbSNP | 7341475 |
| HapMap | 7341475 |
| SNPedia | 7341475 |
| SzGene | Meta-analysis Overview |
In genetics, rs7341475 is a single nucleotide polymorphism (SNP) in the RELN gene that codes the reelin protein. The gene RELN is mapped to human chromosome 7 (7q22.1). The SNP rs7341475 is located in the fourth intron of RELN. The gene RELN has many more SNPs among its 65 exons and 64 introns, — even in intron 4 there are tens of SNPs.[1]
The SNP is currently under investigation for a possible link to schizophrenia. A 2008 genome-wide association study pointed to that a variant of the SNP could elevate the risk for schizophrenia among women.[2]
References[]
- ^ "SNP linked to Gene RELN". NCBI. Retrieved 2008-09-09.
- ^ , , , , David A. Collier, , Kenneth S. Kendler, Tao Li, Michael O'Donovan, , , Dermot Walsh, Daniel R. Weinberger, , Jonathan Flint & Ariel Darvasi (February 2008). "Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women". PLoS Genetics. 4 (2): e28. doi:10.1371/journal.pgen.0040028. PMC 2242812. PMID 18282107.CS1 maint: multiple names: authors list (link) News:
- Eric Metcalf (2008-02-19). "Genetic Variant Found for Women's Schizophrenia". MentalHelp.net. Archived from the original on 2011-07-16. Retrieved 2008-09-09.
- "Gene variant linked to female schizophrenia". PsychiatryMatters.md. 2008-02-25. Archived from the original on 2013-02-19. Retrieved 2008-09-09.
Categories:
- SNPs on chromosome 7